PMID: 9434881Jan 22, 1998Paper

Diaminotoluenes induce intrachromosomal recombination and free radicals in Saccharomyces cerevisiae

Mutation Research
R J Brennan, R H Schiestl

Abstract

The carcinogenicity of aniline-based aromatic amines is poorly reflected by their activity in short-term mutagenicity assays such as the Salmonella typhimurium reverse mutation (Ames) assay. More information about the mechanism of action of such carcinogens is needed. Here we report the effects on DEL recombination in Saccharomyces cerevisiae of the carcinogen 2,4-diaminotoluene and its structural isomer 2,6-diaminotoluene, which is reported to be non-carcinogenic. Both compounds are detected as equally mutagenic in the Salmonella assay. In the absence of any external metabolizing system both compounds were recombinagenic in the DEL assay with the carcinogen being a more potent inducer of deletions than the non-carcinogen. In the presence of Aroclor-induced rat liver S9, however, the carcinogen 2,4-diaminotoluene became a 2-fold more potent inducer of deletions, and the non-carcinogen 2,6-diaminotoluene was rendered less toxic and no induced recombination was observed. 2,4-Diaminotoluene is distinguished from its non-carcinogen analog in the DEL assay, therefore, on the basis of a preferential activation of the carcinogen in the presence of a rat liver microsomal metabolizing system. Free radical species are produced by several...Continue Reading

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Citations

Mar 16, 2001·Biochimica Et Biophysica Acta·A J Bishop, R H Schiestl
Aug 5, 2008·Nitric Oxide : Biology and Chemistry·Claudia BackhausRüdiger Hardeland
Oct 15, 2003·Oncogene·Ramune Reliene, Robert H Schiestl

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