Diaphragmatic fatigue is associated with decreased inositol 1,4,5-trisphosphate formation

The American Review of Respiratory Disease
J H ZaveczL McNatt

Abstract

The ability of the rat diaphragm to produce inositol 1,4,5-trisphosphate (InsP3) in response to a maximal contractile stimulus was determine in vitro in both fatigued and nonfatigued diaphragms. InsP3 was produced during a maximal contraction of the diaphragm. After inducing fatigue, there was a significant reduction in the production of InsP3 compared with that in nonfatigued muscle. The maximal force generated by the diaphragm was also decreased after fatigue. A significant positive linear correlation was found between the force developed by the diaphragm and the amount of InsP3 liberated.

Citations

Sep 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·H Oueslati, P F Gardiner
Feb 1, 1993·Burns : Journal of the International Society for Burn Injuries·J F TomeraS P Kukulka

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