Diarrhea and reduced levels of antiretroviral drugs: improvement with glutamine or alanyl-glutamine in a randomized controlled trial in northeast Brazil

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Oluma Y. BushenR L Guerrant

Abstract

The effects of therapy with glutamine and alanyl-glutamine on diarrhea and antiretroviral drug levels in patients with acquired immune deficiency syndrome (AIDS) were examined in a randomized, double-blinded, placebo-controlled study in northeast Brazil. Patients with AIDS and with diarrhea and/or wasting were randomized into 4 groups to determine the efficacy of glutamine or high- or low-dose alanyl-glutamine given for 7 days, compared with isonitrogenous glycine given to control subjects. All patients in whom baseline antiretroviral drug levels were determined had low levels 2 h after dosing. Gastrointestinal symptom scores improved with receipt of high-dose alanyl-glutamine (P<.05) or glutamine (P<.01). Antiretroviral drug levels increased in patients given alanyl-glutamine (P=.02) or glutamine (P=.03) by 113% (P=.02) and 14% (P=.01), respectively. Antiretroviral drug resistance mutations were common in all groups. The dose-related efficacy of alanyl-glutamine and glutamine in treating diarrhea and in increasing antiretroviral drug levels shows that these supplements may help to improve therapy for patients with AIDS who have diarrhea and/or wasting in developing, tropical areas.

References

Aug 1, 1990·Nutrition Reviews·J M Lacey, D W Wilmore
Apr 1, 1986·Archives of Disease in Childhood·T Vesikari, E Isolauri
Mar 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·U SüttmannM J Müller
Jun 1, 1994·Journal of the American College of Nutrition·H Ribeiro JúniorO Fontaine
May 29, 1993·Lancet·R R van der HulstP B Soeters
May 1, 1993·The American Journal of Tropical Medicine and Hygiene·E D Moreira JúniorW D Johnson
May 21, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D A WheelerG E Bartsch
Oct 3, 1998·Clinical Pharmacology and Therapeutics·C V FletcherH H Balfour
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·T N KakudaC V Fletcher
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A BlikslagerR Argenzio
Sep 18, 2002·Archives of Medical Research·Richard L GuerrantAldo A M Lima
Mar 19, 2003·Current Infectious Disease Reports·Benedito A. Carneiro-FilhoRichard L. Guerrant
Jun 17, 2003·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Richard K BrantleyRichard L Guerrant

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Citations

Jan 18, 2006·Digestive Diseases and Sciences·Maribel Rodríguez-TorresAcisclo M Marxuach-Cuétara
Jan 21, 2006·Current Treatment Options in Gastroenterology·Susan C Morpeth, Nathan M Thielman
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard L GuerrantAldo A M Lima
Jul 30, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Priscilla M UenoSean R Moore
Apr 3, 2008·The Journal of Clinical Investigation·William A PetriRichard L Guerrant
Jun 26, 2008·The Journal of Parasitology·Bruna P CoutinhoRichard L Guerrant
Jun 3, 2011·The American Journal of Tropical Medicine and Hygiene·Rebecca DillinghamDaniel Fitzgerald
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Rachel PeletzThomas Clasen
May 9, 2013·European Journal of Pediatrics·Vania GiacometGian Vincenzo Zuccotti
Feb 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oswald MolingPeter Mian
Aug 30, 2008·Nutrition Reviews·Richard L GuerrantAldo A M Lima
Aug 2, 2006·Gastroenterology Clinics of North America·Richard Goodgame
Aug 2, 2006·Gastroenterology Clinics of North America·David B Huang, A Clinton White
Jul 11, 2007·HIV Clinical Trials·Jill TinmouthRichard Glazier
Aug 7, 2014·BMC Gastroenterology·Camila A A de QueirozReinaldo B Oriá
Oct 15, 2014·The American Journal of Tropical Medicine and Hygiene·Christine Marie GeorgeErik D Lindquist
Mar 17, 2005·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Carla R HeiserMichael P Dube
Aug 7, 2010·Current Opinion in Infectious Diseases·Miguel M Cabada, A Clinton White
Dec 2, 2005·Current Opinion in Gastroenterology·Kerri Thom, Graeme Forrest
Jan 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P Saiz de la HoyaUNKNOWN Prevalhep study group
Feb 28, 2007·Journal of Pediatric Gastroenterology and Nutrition·Noélia L LimaAldo A M Lima
Mar 15, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Travis YatesRobert Quick
Jul 11, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sean R MooreAldo A M Lima
Apr 30, 2009·Expert Review of Anti-infective Therapy·Birte PantenburgA Clinton White
Aug 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sean R MooreAldo A M Lima
Feb 8, 2007·The American Journal of Clinical Nutrition·Paul K DrainWafaie W Fawzi
Jan 23, 2021·Clinical Science·Sandro Massao HirabaraRui Curi
Jul 27, 2021·Nutrition and Cancer·Gang TangZhengqiang Wei

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