Diaryloxy methano phenanthrenes: a new class of antituberculosis agents

Bioorganic & Medicinal Chemistry
Gautam PandaBrahm S Srivastava

Abstract

A new series of diaryloxy methano phenanthrenes were prepared through tertiary-aminoalkylations of [(methoxy-phenyl)-phenanthren-9-yl-methyl]-phenols obtained from Friedel-Crafts alkylations on (methoxy-phenyl)-phenanthren-9-yl-methanols. These series of compounds were evaluated against Mycobacterium tuberculosis H37Rv and showed the desired activity in the range of 6.25 microg/mL in vitro. One of the compound 12j protects the mice from the challenge of M. tuberculosis in vivo, as 30% of the mice were survived at treatment of 50 mg/kg body weight.

References

Mar 1, 1991·Antimicrobial Agents and Chemotherapy·H SaitoT Hidaka
Jan 1, 1995·Annual Review of Biochemistry·P J Brennan, H Nikaido
Jan 1, 1995·Annual Review of Microbiology·D B Young, K Duncan
Jul 1, 1996·Trends in Microbiology·C E Barry, K Mdluli
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·I Chopra, P Brennan
Aug 31, 1999·Carbohydrate Research·R C ReynoldsJ A Maddry
Mar 29, 2000·Journal of Bacteriology·R A Kanaly, S Harayama
May 7, 2002·Natural Product Letters·Joseph K Rugutt, Kipngeno J Rugutt
Sep 28, 2002·European Journal of Medicinal Chemistry·R P TripathiB S Srivastava
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Suzanne J SeniorGurdyal S Besra

❮ Previous
Next ❯

Citations

Jul 22, 2006·Journal of Molecular Modeling· ShaguftaMohammad Imran Siddiqi
Nov 21, 2007·Antimicrobial Agents and Chemotherapy·Sanjay KumarUday Bandyopadhyay
Aug 14, 2009·Letters in Applied Microbiology·V Praveen, C K M Tripathi
Feb 1, 2020·Bioorganic Chemistry·Christophe RiccoMaité Sylla-Iyarreta Veitía
Apr 22, 2014·Journal of the American Chemical Society·Jiadi ZhangPatrick J Walsh
Aug 2, 2018·The Journal of Organic Chemistry·Maozhong MiaoHongjun Ren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

Bioorganic & Medicinal Chemistry Letters
Sajal Kumar DasSudhir Kumar Sinha
European Journal of Medicinal Chemistry
Gautam PandaSudhir Kumar Sinha
Bioorganic & Medicinal Chemistry Letters
Maloy Kumar ParaiSudhir Kumar Sinha
Bioorganic & Medicinal Chemistry Letters
Fátima M F VergaraMarcus V N De Souza
© 2021 Meta ULC. All rights reserved