Abstract
Although diastolic blood pressure (DBP) is independently associated with an increased risk of adverse cardiovascular outcomes in the general population, it is unclear if a similar relationship exists in patients with heart failure with preserved ejection fraction. This analysis included 1703 (mean age, 72±10 years; 50% men; 78% white) patients with heart failure with preserved ejection fraction enrolled in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial from the Americas who were treated for hypertension. Multivariable Cox regression was used to examine the risk of hospitalization for heart failure, death, and cardiovascular death associated with DBP. The relationship between hospitalization for heart failure and DBP was linear, with an increased risk observed with decreasing DBP values (≥90 mm Hg: referent; 80-89 mm Hg: hazard ratio [HR], 1.44; 95% confidence interval [CI], 0.85-2.44; 70-79 mm Hg: HR, 1.18; 95% CI, 0.69-2.01; 60-69 mm Hg: HR, 1.54; 95% CI, 0.90-2.63; <60 mm Hg: HR, 2.12; 95% CI, 1.20-3.74;P=0.0055 for trend). The associations of DBP with death (≥90 mm Hg: HR, 1.86; 95% CI, 1.12-3.06; 80-89 mm Hg: HR, 1.23; 95% CI, 0.89-1.70; 70-79 mm Hg: referent; 60-69 m...Continue Reading
References
May 22, 1996·JAMA : the Journal of the American Medical Association·D LevyK K Ho
Jun 21, 2006·Annals of Internal Medicine·Franz H MesserliCarl J Pepine
Jan 21, 2010·Statistics in Medicine·Loic Desquilbet, François Mariotti
Dec 6, 2011·American Heart Journal·Akshay S DesaiMarc A Pfeffer
Dec 22, 2012·Circulation. Heart Failure·Sanjiv J ShahRebecca Li
Dec 20, 2013·JAMA : the Journal of the American Medical Association·Paul A JamesEduardo Ortiz
Apr 11, 2014·The New England Journal of Medicine·Bertram PittUNKNOWN TOPCAT Investigators
Jun 22, 2014·Circulation Research·Kavita Sharma, David A Kass
Nov 20, 2014·Circulation·Marc A PfefferBertram Pitt
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Jun 9, 2016·Circulation. Heart Failure·Jennifer E HoMartin G Larson
Jul 1, 2016·Circulation·Sanjiv J ShahWalter J Paulus
Sep 4, 2016·Journal of the American College of Cardiology·John W McEvoyElizabeth Selvin
Sep 4, 2016·Lancet·Emmanuelle Vidal-PetiotUNKNOWN CLARIFY Investigators
Apr 30, 2017·Circulation·Clyde W YancyCheryl Westlake
Sep 3, 2017·The American Journal of Cardiology·Faisal RahmanJohn W McEvoy
Citations
Jan 5, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Sang-Hyun IhmKwang Kon Koh
Jul 10, 2019·The Journal of Clinical Hypertension·Maria E MarketouFragiskos I Parthenakis
Sep 28, 2018·Current Cardiology Reports·Faisal Rahman, John W McEvoy
Aug 5, 2020·Journal of the American Heart Association·Fang-Fei WeiChen Liu
Apr 23, 2020·ESC Heart Failure·Mengxi YangJingyi Ren
Dec 2, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Yuzhong WuChen Liu
Feb 3, 2021·Heart and Vessels·Aya FuchidaKoichiro Kuwahara
Feb 24, 2021·Journal of the American Heart Association·Haekyung Jeon-SlaughterRamin Ebrahimi
Mar 30, 2021·Hypertension·Fang-Fei WeiChen Liu
Mar 13, 2021·Current Opinion in Cardiology·Peder L MyhreScott D Solomon
Aug 6, 2021·BMC Cardiovascular Disorders·Chu ZhengYanbo Zhang