Diastolic blood pressure is a potentially modifiable risk factor for preeclampsia in women with pre-existing diabetes

Diabetes Research and Clinical Practice
Sidse Kjærhus NørgaardElisabeth R Mathiesen

Abstract

To identify early clinical, modifiable risk factors for preeclampsia present at first antenatal visit and assess the prevalence of pregnancy-related hypertensive disorders in women with pre-existing diabetes treated with tight glycemic and blood pressure (BP) control. A population-based cohort study of 494 women with pre-existing diabetes (307 and 187 women with type 1 and type 2 diabetes, respectively), included at their first antenatal visit from 2012 to 2016. The prevalence of chronic hypertension (without diabetic nephropathy or microalbuminuria), gestational hypertension and preeclampsia was recorded. Diabetic microangiopathy included presence of nephropathy, microalbuminuria and/or retinopathy. Treatment target was BP <135/85 mmHg. HbA1c was 6.9 ± 2.4% (50 ± 12 mmol/mol) at first antenatal visit and 6.0 ± 0.6% (43 ± 6 mmol/mol) before delivery with no differences between women with type 1 and type 2 diabetes. At the first antenatal visit, the prevalence of microalbuminuria was 6% (6% vs. 6%), nephropathy 2% (1% vs. 2%) and chronic hypertension 6% (3% vs. 10%, p = 0.03). Gestational hypertension developed in 8% (9% vs. 6%) and preeclampsia developed in 8% (9% vs. 7%). Presence of diabetic microangiopathy (adjusted odds rat...Continue Reading

Citations

Jun 25, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Miki AkushichiAkitoshi Yoshida
Dec 27, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Maria Lúcia Da Rocha OppermannAngela Jacob Reichelt
Nov 30, 2019·Acta Diabetologica·Nicoline Callesen DoElisabeth Reinhardt Mathiesen
Jul 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hua LaiHuai Liu
Sep 9, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jieyu LiuJieyun Yin
Apr 6, 2019·Nature Reviews. Endocrinology·Lene RingholmElisabeth R Mathiesen
Oct 16, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Marianne VestgaardElisabeth R Mathiesen

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