Diastolic function parameters are improved by the addition of simvastatin to enalapril-based treatment in hypertensive individuals

Atherosclerosis
Adenalva L S BeckAndrei C Sposito

Abstract

Diastolic dysfunction (DD) is a frequent condition in hypertensive patients whose presence increases mortality and whose treatment remains unclear. The aim of this study was to investigate in a prospective, double-blinded, placebo-controlled randomized design the additive effect of simvastatin on DD in enalapril-treated hypertensive patients with average cholesterol levels. Hypertensive patients with DD and LDL-cholesterol <160 mg/dL underwent a run-in phase to achieve a systolic blood pressure (SBP) <135 mmHg and diastolic blood pressure (DBP) <85 mmHg with enalapril. Hydrochlorothiazide was added when need to achieve blood pressure control. Four weeks after reaching the optimum anti-hypertensive regimen patients were randomized to receive 80 mg simvastatin (n=27) or placebo (n=28) for a period of 20 weeks. Echocardiograms were performed before and after treatment with measurement of maximum left atrial volume (LAV), conventional and tissue Doppler velocities in early diastole (E, e') and late diastole (A, a'). After 20 weeks, the simvastatin group presented reduction in SBP (-4±2 mmHg, p=0.02), increase in E/A ratio (1.0±0.05 to 1.2±0.06, p=0.03) and decrease of LAV indexed to body surface area (24.5±0.9 to 21.1±0.8 ml/m(2), ...Continue Reading

Associated Clinical Trials

References

Sep 28, 2001·Journal of the American Podiatric Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
Jun 27, 2002·Journal of the American College of Cardiology·Giuseppe SchillaciElmo Mannarino
Aug 3, 2002·Hypertension·M Mitchell LindsayFrancis G Dunn
Oct 10, 2002·The American Journal of Cardiology·Maurizio GalderisiOreste de Divitiis
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jun 20, 2006·Journal of the American College of Cardiology·Walter P AbhayaratnaTeresa S M Tsang
Feb 21, 2007·Hypertension·Pasquale StrazzulloFrancesco P Cappuccio
Feb 19, 2008·Journal of the American College of Cardiology·Steven J LesterJames B Seward
Nov 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·George NtaiosApostolos Hatzitolios

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