Diastolic hypotension in pediatric patients with asthma receiving continuous albuterol

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Sarah WisecupRicardo Alberto Mosquera

Abstract

Concerns have been raised regarding cardiac side effects of continuous high-dose albuterol nebulization in status asthmaticus management. Our study goal was to determine prevalence and potential risk factors for hypotension development during continuous albuterol administration in pediatric patients. A retrospective cohort study was conducted at Children's Memorial Hermann Hospital from 1 January 2011 to 31 August 2012. A total of 152 patients admitted to pediatric intensive or intermediate care units who received continuous albuterol nebulization for management of status asthmaticus were analyzed. Diastolic hypotension, defined as a value < 50 mmHg or <5th percentile of normal for age, developed in 90% of patients and a positive correlation with increasing doses of albuterol was demonstrated. The overall median time to onset of hypotension was 4 h (interquartile range (IQR): 2-6.5) and was significantly lower among patients admitted to the intensive care unit rather than intermediate care (p = 0.005). The odds of hypotension were 82% lower among patients who received fluid boluses prior to continuous albuterol nebulization. None of the potential risk factors demonstrated statistical significance. Diastolic hypotension is a com...Continue Reading

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Citations

Jan 9, 2016·Respiratory Medicine Case Reports·Tehila A SaadiaHaesoon Lee
Apr 17, 2018·Pediatric Pulmonology·Ryan L DeSantiMohammed J Hussain
May 24, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ada T LinTodd J Karsies
Jul 11, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Raymond Parlar-ChunMani Singh
Jan 10, 2018·Medicinal Research Reviews·Přemysl MladěnkaUNKNOWN TOX-OER and CARDIOTOX Hradec Králové Researchers and Collaborators
Jan 30, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Raymond Parlar-Chun, Kristen Arnold
Mar 29, 2021·Resuscitation·Patrick Van de VoordeIan Maconochie
Jun 8, 2021·Notfall & Rettungsmedizin·Patrick Van de VoordeIan Maconochie

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