PMID: 6221744Jun 1, 1983Paper

Diastolic mechanisms of impaired exercise tolerance in aortic valve disease

British Heart Journal
P J OldershawD G Gibson


In order to determine the significance of abnormalities of diastolic function in patients with left ventricular hypertrophy, exercise echocardiography to heart rates of 140 to 150 beats/min was performed in 18 normal subjects and 14 patients after aortic valve replacement. Simultaneous echo-, phono-, and electrocardiograms were recorded. Left ventricular cavity size was determined at end-diastole and end-systole. The timing of mitral valve opening and closure was measured, and hence left ventricular filling time derived, expressed either as ms/beat, or s/min when multiplied by heart rate. Isovolumic relaxation was taken as the interval between A2 and mitral valve opening. Systolic function, assessed from cavity dimensions, peak VCF, and QA2 interval was normal in all but two patients at rest and on exercise. Isovolumic relaxation was prolonged at rest in the patients to 85 +/- 8 ms (normal 69 +/- 9 ms), but left ventricular filling times were normal. With exercise, in normal subjects, isovolumic relaxation remained constant, but filling times dropped strikingly from 380 +/- 66 ms/beat, or 27 +/- 2 s/min at rest to 115 +/- 10 ms/beat or 16 +/- 2 s/min. In patients with left ventricular hypertrophy, isovolumic relaxation dropped ...Continue Reading


Jan 1, 1979·British Heart Journal·D G GibsonD J Brown
Jul 1, 1979·British Heart Journal·W Chen, D Gibson
Mar 1, 1978·Progress in Cardiovascular Diseases·M T Upton, D G Gibson
Mar 1, 1976·British Heart Journal·D Weisdorf, D H Spodick
Mar 1, 1964·Journal of Applied Physiology·P O ASTRANDJ STENBERG

❮ Previous
Next ❯


Jan 22, 2009·JAMA : the Journal of the American Medical Association·Jasmine GrewalPatricia A Pellikka
Oct 12, 2000·Journal of the American College of Cardiology·P Pibarot, J G Dumesnil
Sep 1, 1985·Journal of the American College of Cardiology·S D ColanK M Borow
Jan 31, 1985·The New England Journal of Medicine·E J TopolN J Fortuin
Oct 1, 1983·British Heart Journal·W K Hui, D G Gibson
Apr 1, 1984·British Heart Journal·A CieslinskiD Gibson
Aug 1, 1987·British Heart Journal·P Van Leeuwen, H C Kuemmell
Jan 1, 1989·British Journal of Clinical Pharmacology·H PouleurM F Rousseau
Apr 29, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Vittorio PalmieriRiccardo Pini
Feb 26, 2009·Angiology·Dimitris P Papadopoulos, Vasilios Papademetriou
Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·L S GoodmanW C Ammann

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.