PMID: 6221744Jun 1, 1983Paper

Diastolic mechanisms of impaired exercise tolerance in aortic valve disease

British Heart Journal
P J OldershawD G Gibson

Abstract

In order to determine the significance of abnormalities of diastolic function in patients with left ventricular hypertrophy, exercise echocardiography to heart rates of 140 to 150 beats/min was performed in 18 normal subjects and 14 patients after aortic valve replacement. Simultaneous echo-, phono-, and electrocardiograms were recorded. Left ventricular cavity size was determined at end-diastole and end-systole. The timing of mitral valve opening and closure was measured, and hence left ventricular filling time derived, expressed either as ms/beat, or s/min when multiplied by heart rate. Isovolumic relaxation was taken as the interval between A2 and mitral valve opening. Systolic function, assessed from cavity dimensions, peak VCF, and QA2 interval was normal in all but two patients at rest and on exercise. Isovolumic relaxation was prolonged at rest in the patients to 85 +/- 8 ms (normal 69 +/- 9 ms), but left ventricular filling times were normal. With exercise, in normal subjects, isovolumic relaxation remained constant, but filling times dropped strikingly from 380 +/- 66 ms/beat, or 27 +/- 2 s/min at rest to 115 +/- 10 ms/beat or 16 +/- 2 s/min. In patients with left ventricular hypertrophy, isovolumic relaxation dropped ...Continue Reading

References

Jan 1, 1979·British Heart Journal·D G GibsonD J Brown
Jul 1, 1979·British Heart Journal·W Chen, D Gibson
Mar 1, 1978·Progress in Cardiovascular Diseases·M T Upton, D G Gibson
Mar 1, 1976·British Heart Journal·D Weisdorf, D H Spodick
Mar 1, 1964·Journal of Applied Physiology·P O ASTRANDJ STENBERG

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Citations

Jan 22, 2009·JAMA : the Journal of the American Medical Association·Jasmine GrewalPatricia A Pellikka
Oct 12, 2000·Journal of the American College of Cardiology·P Pibarot, J G Dumesnil
Sep 1, 1985·Journal of the American College of Cardiology·S D ColanK M Borow
Jan 31, 1985·The New England Journal of Medicine·E J TopolN J Fortuin
Oct 1, 1983·British Heart Journal·W K Hui, D G Gibson
Apr 1, 1984·British Heart Journal·A CieslinskiD Gibson
Aug 1, 1987·British Heart Journal·P Van Leeuwen, H C Kuemmell
Jan 1, 1989·British Journal of Clinical Pharmacology·H PouleurM F Rousseau
Apr 29, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Vittorio PalmieriRiccardo Pini
Feb 26, 2009·Angiology·Dimitris P Papadopoulos, Vasilios Papademetriou
Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·L S GoodmanW C Ammann

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