PMID: 332103Sep 1, 1977Paper

Diazepam-induced coma with bullae and eccrine sweat gland necrosis

Archives of Internal Medicine
A O VarmaM K Sarin

Abstract

Bullous skin lesions that indicate sweat gland necrosis have been known to occur in drug-induced coma resulting from barbiturates and in carbon monoxide poisoning. To our knowledge, this is the first cases in which diazepam is implicated in causing bullous lesions over pressure points, and the first case showing on biopsy specimen eccrine sweat gland and sweat duct necrosis. Penile and oral lesions are being described here for the first time to our knowledge. The following mechanisms could be responsible for the skin lesions: hypoxia, local pressure, hyperthermia with excessive sweating, and a specific toxic effect on the eccrine gland. With the increasing use of the benzodiazepines, such lesions could be seen more frequently in the future.

Citations

Jan 1, 1990·Journal of Toxicology. Clinical Toxicology·M MoshkowitzY Levo
Oct 24, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·W S Waring, E A Sandilands
Jul 31, 2018·Current Drug Research Reviews·Ricardo J Dinis-Oliveira
Jan 22, 2013·The American Journal of Dermatopathology·Anna H ChaconGeorge W Elgart

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