PMID: 9546579Apr 18, 1998Paper

Diazepam induced early oxidative changes at the subcellular level in rat brain

Molecular and Cellular Biochemistry
S Musavi, P Kakkar

Abstract

Studies were conducted to ascertain any involvement of free radical mediated prooxidative processes in different brain regions following diazepam administration. A significant decrease in TBA reactive substance formation was observed in cerebral cortex, cerebellum and brain stem regions after single doses of 1.5, 3 and 6 mg/kg b.wt. For further studies rats were given diazepam (i.p.) at 3 mg/kg body weight dose and sacrificed after 1 h to follow changes in the pro/antioxidant status. An enhancement in the TBARS formation was found in the mitochondrial fractions from cerebral cortex and brain stem. This effect was highest in brain stem being 107% as compared to controls. In the post mitochondrial fraction, cerebellum showed 49% enhancement whereas decreased formation of thiobarbituric acid reactive substances was observed in cerebral cortex and brain stem. Isozymes of superoxide dismutase showed a decrease in activity which was region dependent. Even though, total thiols were not significantly altered, free thiols showed depletion in cerebellum (39.8%) and brain stem (50%). Glutathione reductase activity was also decreased in cerebellum and brain stem. The results indicate that a single dose of diazepam causes free radical media...Continue Reading

Citations

Apr 26, 2016·Journal of Biochemical and Molecular Toxicology·Guilherme André EgerDébora Delwing Dal Magro
Apr 19, 2016·Anesthesia and Analgesia·Siamak DjafarzadehStephan M Jakob
Mar 9, 2018·Journal of Applied Toxicology : JAT·Nela VanovaDaniel Jun
Nov 4, 2006·Biological Chemistry·Freimut SchliessDieter Häussinger
Jul 16, 2008·Molecular Nutrition & Food Research·John Neustadt, Steve R Pieczenik
Dec 16, 2017·Journal of Biochemical and Molecular Toxicology·Mohammad Javad KhoshnoudMarzieh Rashedinia
Jan 17, 2009·Metabolic Brain Disease·Freimut SchliessDieter Häussinger
May 15, 2015·Journal of Cellular Biochemistry·Rafael NaglerMoshe Gavish
Jun 8, 2011·Basic & Clinical Pharmacology & Toxicology·Luis A Méndez-CuestaPaul Carrillo-Mora
Mar 26, 2010·Journal of Psychiatric Research·Samira S ValvassoriJoão Quevedo

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