Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788

European Journal of Pharmacology
M H ThiébotP Simon

Abstract

The effects of the benzodiazepine receptor antagonist Ro 15-1788, an imidazobenzodiazepine derivative, were studied with respect to three pharmacological activities exerted by diazepam in rats. Two of these, release of shock-induced suppression of drinking and attenuation of non-reward-induced cessation of responding for food, reflect the anxiolytic property of benzodiazepines. The amnesic-like effect of diazepam was also investigated. Ro 15-1788 (in doses ranging from 4 to 16 mg/kg p.o.) completely reversed diazepam (2 mg/kg)-induced release of behavior in both punishment and non-reward procedures. In contrast, Ro 15-1788 reduced but did not completely abolish diazepam-induced amnesia. These data suggest that the anticonflict and anti-frustration effects of benzodiazepines probably involve similar receptor types which nevertheless differ from those chiefly implicated in the amnesic-like activity of benzodiazepines.

References

Jan 1, 1971·Psychopharmacologia·J R VogelD E Clody
Mar 26, 1981·European Journal of Pharmacology·H RommelspacherU Wollert
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C BraestrupC E Olsen
Apr 9, 1981·Nature·W HunkelerW Haefely
Feb 19, 1981·European Journal of Pharmacology·P SkolinickJ Cook
Jan 1, 1982·Psychopharmacology·E P BonettiW Haefely
Oct 1, 1982·Neuropharmacology·S E FileD J Nutt

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Citations

Jan 1, 1986·Psychopharmacology·S E File, S Pellow
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·K A Grant, C E Johanson
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·H L KomiskeyK L Mundinger
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·A V TitievskyM M Airaksinen
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R G Lister
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·M H Thiébot
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·S O Cole
May 1, 1990·Behavioral and Neural Biology·S O Cole
Jan 1, 1990·Pharmacology & Therapeutics·C F Flaherty
Jun 1, 1996·Brain Research. Cognitive Brain Research·J C Bizot, M H Thiébot
Feb 1, 1997·Pharmacology, Biochemistry, and Behavior·A Saldívar-GonzálezR Mondragón-Ceballos
Oct 20, 1998·Acta Psychiatrica Scandinavica. Supplementum·P Martin
Sep 30, 2003·Journal of Psychopharmacology·Anne JacksonDavid N Stephens

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