Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation.

The Journal of Organic Chemistry
Evgeny KiselevMark Cushman

Abstract

Dibenzo[c,h][1,5]naphthyridinediones were prepared via a novel synthetic pathway. The compounds were designed as topoisomerase I (Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that, unlike very closely related dibenzo[c,h][1,6]naphthyridinediones, dibenzo[c,h][1,5]naphthyridinediones retain the Top1 inhibitory activity of similarly substituted indenoisoquinolines.

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Citations

Aug 1, 2015·Organic Letters·Dmitry Dar'inMikhail Krasavin
Apr 25, 2013·Expert Opinion on Therapeutic Patents·Daulat B Khadka, Won-Jea Cho
Jan 11, 2017·Journal of Medicinal Chemistry·Giovanni CapranicoGiovanni Chillemi
May 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elizaveta KarchuganovaMikhail Krasavin
Nov 28, 2020·Chemical Communications : Chem Comm·Ali WangYuanhong Liu
Mar 9, 2013·Journal of the American Chemical Society·Qiuzheng TangCongyang Wang

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