Diblock Polymer Brush (PHEAA- b-PFMA): Microphase Separation Behavior and Anti-Protein Adsorption Performance

Langmuir : the ACS Journal of Surfaces and Colloids
Hai-Xia WuChuan-Jun Liu

Abstract

In this paper, a series of amphiphilic diblock polymers of poly(hydroxyethylacrylamide)- b-poly(1H,1H-pentafluoropropyl methacrylate) (PHEAA- b-PFMA) were grafted from silicon wafer via surface-initiated atom transfer radical polymerization (SI-ATRP). Surface wettability and chemical compositions of the modified surfaces were characterized by contact angle goniometer and X-ray photoelectron spectroscopy (XPS) respectively. Molecular weight and polydispersity of each block were measured using gel permeation chromatography (GPC). The topography and the microphase separation behavior of PHEAA- b-PFMA surfaces were investigated by atomic force microscope (AFM). The results show that only when the grafting density (σ) and thickness of PHEAA brush were in the range of 0.9-1.3 (chain/nm2) and 6.6-15.1 nm, respectively, and the ratio of PFMA/PHEAA varied from 89/42 to 89/94, could the diblock copolymer phase separate into nanostructures. Further, the antiprotein adsorption performance of the modified surfaces against BSA, fibrinogen, and lysozyme was studied. The results indicated the modified surfaces could reduce the protein adsorption compared to the pristine silicon wafer. For Fibrinogen, the antiadsorption effect of PHEAA- b-PFMA-...Continue Reading

References

Aug 1, 2000·Colloids and Surfaces. B, Biointerfaces·N Wisniewski, M Reichert
Feb 13, 2007·Small·Prashanth AsuriJonathan S Dordick
Aug 28, 2009·Investigative Ophthalmology & Visual Science·Nerida ColeMark D P Willcox
Sep 16, 2009·Expert Review of Medical Devices·Krasimir VasilevHans J Griesser
May 11, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Lei Shen, X-Y Zhu
Feb 22, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Stella BauerAxel Rosenhahn
Dec 18, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaoying ZhuG Julius Vancso
Jan 23, 2014·Biofouling·Melissa L HawkinsMelissa A Grunlan
Mar 13, 2014·ACS Applied Materials & Interfaces·Carlo A AmadeiSergio Santos
Mar 13, 2015·ACS Applied Materials & Interfaces·Pengxiang JiaJiang Zhao
Jan 16, 2016·Biomacromolecules·Stella BauerAxel Rosenhahn
Mar 18, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Hong ChenJie Zheng
Jun 16, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Zhanhua Wang, Han Zuilhof
Dec 17, 2016·ACS Applied Materials & Interfaces·Jin GuPeng Yang
Mar 8, 2017·Macromolecular Rapid Communications·Giancarlo Galli, Elisa Martinelli
Nov 5, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Haiye WangChunju He
Dec 2, 2017·Advanced Healthcare Materials·Izabela Firkowska-BodenKlaus D Jandt
Mar 28, 2018·Advanced Materials·Krzysztof Matyjaszewski
Feb 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lei ShenJintao Zhu
Jun 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lin WangYanqing Yao
Sep 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan LiuJing-Hui Zhang

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