Diboron-Catalyzed Dehydrative Amidation of Aromatic Carboxylic Acids with Amines

Organic Letters
Dinesh N SawantSusumu Saito

Abstract

Tetrakis(dimethylamido)diboron and tetrahydroxydiboron are herein reported as new catalysts for the synthesis of aryl amides by catalytic condensation of aromatic carboxylic acids with amines. The developed protocol is both simple and highly efficient over a broad range of substrates. This method thus represents an attractive approach for the use of diboron catalysts in the synthesis of amides without having to resort to stoichiometric or additional dehydrating agents.

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Citations

Oct 13, 2018·Chemical Communications : Chem Comm·Shota Yoshioka, Susumu Saito
Feb 9, 2019·Organic & Biomolecular Chemistry·Kenichi MichigamiYoshiji Takemoto
Feb 17, 2019·Chemistry : a European Journal·Christopher R OpieNaoya Kumagai
Jun 22, 2019·Organic & Biomolecular Chemistry·Charlotte E CoomberTom D Sheppard
Oct 22, 2019·Chemistry : a European Journal·Takeshi NanjoYoshiji Takemoto
Mar 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Blessing D MkhonaziPaseka T Moshapo
Oct 3, 2020·Chemical Communications : Chem Comm·Naoyuki ShimadaKazuishi Makino

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