Dibromochloropropane (DBCP): a 17-year reassessment of testicular function and reproductive performance

Journal of Occupational and Environmental Medicine
Gad Potashnik, A Porath

Abstract

The current study summarizes a 17-year reevaluation of testicular function and reproductive performance of 15 production workers with dibromochloropropane (DBCP)-induced testicular dysfunction. Sperm count recovery was evident within 36 to 45 months in three of the nine azoospermic and in three of the six oligozoospermic men with no improvement thereafter. A significant increase in plasma follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and a nonsignificant decrease in testosterone level were detected in the severely affected individuals. There was no increase in the rate of spontaneous abortions and congenital malformations among pregnancies conceived during or after exposure. A low prevalence of male infants conceived during paternal exposure was found as compared with the preexposure period (16.6% versus 52.9%; P<.025). Restoration of fertility was followed by a gradual increase of this value to 41.4%.

Citations

May 22, 2003·Reproductive Toxicology·Marvin L MeistrichKaren L Porter
Jun 23, 1999·Reproductive Toxicology·G K LemastersG B Huszar
Apr 17, 2010·Human Reproduction·Egbert te VeldeDik Habbema
Jul 31, 2013·Integrative and Comparative Biology·Kristen J Navara
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew K HotchkissL Earl Gray
Dec 26, 2002·Journal of Occupational and Environmental Medicine·Einat K SheinerIlana Shoham-Vardi
Feb 24, 1998·Annals of the New York Academy of Sciences·J R Goldsmith
Feb 6, 2007·BMJ : British Medical Journal·Mike JoffeTina Kold Jensen
Mar 10, 2007·BMJ : British Medical Journal·Jens Peter Ellekilde Bonde, Allen Wilcox
Nov 23, 2007·Journal of Agromedicine·Linda M Frazier
Aug 6, 2003·Archives of Environmental Health·Irene Figà-TalamancaLaura Ulizzi
May 10, 1997·Lancet·M Paul
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Warren G FosterMiguel M Dominguez
Jan 1, 2011·Emerging Health Threats Journal·Metrecia L TerrellMichele Marcus
Nov 10, 2000·Primary Care·L M Frazier
May 5, 2016·Seminars in Cell & Developmental Biology·Filipe Tenorio Lira NetoMarc Goldstein
Mar 30, 2002·Cadernos de saúde pública·Sergio KoifmanArmando Meyer
Mar 30, 2002·Cadernos de saúde pública·Marcos Mitsuyoshi MoriMiguel Srougi
Dec 19, 2013·Human & Experimental Toxicology·Pallav Sengupta, Rajdeb Banerjee
Dec 17, 2004·Human Reproduction Update·Edward V YounglaiWarren G Foster
Nov 23, 2007·American Journal of Industrial Medicine·Samuel Milham, Eric M Ossiander
Mar 14, 2003·Journal of Andrology·Marvin L Meistrich, Gunapala Shetty
Nov 8, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H-C Schuppe, F-M Köhn
Jun 19, 2016·Der Urologe. Ausg. A·F-M Köhn, H C Schuppe

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