PMID: 12759094May 22, 2003Paper

Dibromochloropropane inhibits spermatogonial development in rats

Reproductive Toxicology
M L MeistrichKaren L Porter

Abstract

Exposure to the nematocide dibromochloropropane (DBCP) has caused prolonged oligo- and azoospermia in men. There are questions regarding the cellular targets resulting in this effect. In this study we characterized an animal model, in which four daily injections of DBCP produced prolonged oligospermia in LBNF(1) rats without any indication of recovery. Between 6 and 20 weeks after DBCP treatment, 70% of seminiferous tubules showed an epithelium with Sertoli cells but no differentiating germ cells. About 20% of tubules contained differentiating germ cells and 10% showed occlusion or major morphologic alterations to Sertoli cells. Since gonadotropin levels and intratesticular testosterone (ITT) concentrations were elevated in the DBCP-treated rats, the failure of spermatogonial development could not have been a result of lack of these hormones. The tubules without differentiating germ cells contained actively proliferating and dividing type A spermatogonia, which underwent apoptosis instead of differentiation. Thus, the target for the damaging effect appears not to be the killing of stem spermatogonia, but the loss of their ability to undergo differentiation. The presence of type A spermatogonia in the atrophic tubules indicates ...Continue Reading

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Citations

May 22, 2007·Regulatory Toxicology and Pharmacology : RTP·M P Dent
Feb 1, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jeffrey S MoffitMichael S Thibodeau
Jan 1, 2006·Environmental Toxicology and Pharmacology·B Saradha, P P Mathur
Nov 14, 2006·Environmental Research·Marie VahterDeborah Cory-Slechta
Nov 25, 2005·Endocrinology·Karen L PorterMarvin L Meistrich

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis