Dibutyl-phthalate exposure from mesalamine medications and serum thyroid hormones in men

International Journal of Hygiene and Environmental Health
Feiby L NassanRuss Hauser

Abstract

Dibutyl phthalate (DBP) is an endocrine disruptor and used in some medication coatings, such as mesalamine for treatment inflammatory bowel disease (IBD). To determine whether high-DBP from some mesalamine medications alters thyroid function. Seventy men with IBD, without thyroid disease or any radiation history participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback). Men on non-DBP mesalamine (background exposure) at baseline crossed-over to DBP-mesalamine (high exposure) then crossed-back to non-DBP mesalamine (B1HB2-arm) and vice versa for men on DBP-mesalamine at baseline (H1BH2-arm). Serum concentrations of total triiodothyronine (T3), total thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb). After crossover in B1HB2-arm (26 men, 134 samples), T3 decreased 10% (95% confidence interval (CI): 14%,-5%), T3/T4 ratio decreased 8% (CI: 12%,-3%), TPOAb, and TgAb concentrations decreased, 11% (-20%, -2%) and 15% (-23%, -5%), respectively; after crossback, they increased. When men in the H1BH2-arm (44 men, 193 samples) crossed-over, T3 ...Continue Reading

Citations

Jul 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Matthew GencoRobert M Sargis
Aug 29, 2019·Scientific Reports·Molly EstillStephen A Krawetz
Aug 20, 2019·Environmental Science & Technology·Mandy FisherÉric Gaudreau
Jan 15, 2022·Environmental Science and Pollution Research International·Wei WuLiu Cao

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