dic(4;17)(p11;p11): a new recurrent chromosomal abnormality in chronic B-lymphoid disorders

Genes, Chromosomes & Cancer
Evelyne Callet-BauchuP Felman

Abstract

We describe a new nonrandom rearrangement, dic(4;17)(p11;p11), which was identified in three patients with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL). All three cases had in common atypical morphological features with a significant component of prolymphocytes, an unusual clinical outcome, and were refractory to chemotherapy. To further define the cytogenetic breakpoints, we investigated the cases by whole chromosome painting and fluorescence in situ hybridization (FISH) with centromeric probes. FISH analysis detected the same cytogenetic rearrangement in all patients, suggesting that the dic(4;17)(p11;p11) is a recurrent translocation in SLL/CLL. Moreover, FISH analysis showed a monoallelic deletion of the TP53 gene in all cases, suggesting a correlation with the aggressive course of the disease and the clinical outcome observed in these patients.

References

Jan 1, 1978·Cancer·F R Dick, R D Maca
May 1, 1995·Genes, Chromosomes & Cancer·H RiederC Fonatsch
Mar 1, 1995·Leukemia & Lymphoma·M A PirisP Martinez

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Citations

Jun 9, 2007·Cancer Genetics and Cytogenetics·Sophie GazzoEvelyne Callet-Bauchu
Dec 14, 2011·British Journal of Haematology·Cristina LópezAna Carrió
Sep 29, 1999·Genes, Chromosomes & Cancer·E Callet-BauchuP Felman
Jul 28, 2006·The American Journal of Dermatopathology·Arnaud de la FouchardiereFrançoise Berger
Jan 6, 2004·European Journal of Haematology·Roxana CerretiniIrma Slavutsky

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