PMID: 7541644May 1, 1995Paper

dic(9;20): a new recurrent chromosome abnormality in adult acute lymphoblastic leukemia

Genes, Chromosomes & Cancer
H RiederC Fonatsch

Abstract

Loss of chromosome 20 and rearrangement of the short arm of chromosome 9 were identified by banding analysis of three adult patients with acute lymphoblastic leukemia (ALL). The G-banding pattern suggested an identical deletion of 9p, but, also, an unbalanced translocation with chromosome 20 was taken into consideration. Dual-color chromosome painting with probes for chromosomes 9 and 20 revealed the presence of material from chromosome 20 at the short arm of the abnormal chromosome 9 in all three cases. Centromeric alpha-satellite DNA of both chromosome 9 and chromosome 20 was demonstrated by fluorescence in situ hybridization and indicated the presence of a dicentric chromosome. The hybridization of a YAC clone of the short arm of chromosome 20 proved that the dicentric chromosome contained the short arm of chromosome 20, which had been suspected from the G-banding pattern. Thus, the rearrangement was interpreted as dic(9;20)(p11;q11.?1). Because this was the sole chromosome abnormality in two patients, dic(9;20) may be a primary chromosome aberration in ALL. In one case, a 9q+ chromosome derived from a Philadelphia (Ph) translocation was involved in the formation of the dicentric chromosome. Immunophenotyping revealed CD10+ ...Continue Reading

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Citations

Nov 1, 1996·Genes, Chromosomes & Cancer·E Callet-BauchuP Felman
Mar 14, 2002·Cancer Genetics and Cytogenetics·Constantina SambaniCristina Mecucci
Nov 7, 2002·Cancer Genetics and Cytogenetics·Crisoula PatsourisLynda J Campbell
Jun 1, 1997·Cancer Genetics and Cytogenetics·R L StarzaC Mecucci
Mar 11, 2004·Blood Reviews·Krzysztof MrózekClara D Bloomfield
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Qian AnJon C Strefford
Dec 14, 2011·British Journal of Haematology·Cristina LópezAna Carrió
May 20, 1999·American Journal of Hematology·F WimazalP Valent

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