DICE (dexamethasone, ifosfamide, cisplatin, etoposide) as salvage therapy in non-Hodgkin's lymphomas

Leukemia & Lymphoma
P E GossS B Sutcliffe

Abstract

Between April 1988 and April 1992 we conducted a study of DICE (dexamethasone 10 mg q6h, ifosfamide 1 g/m2, cisplatin 25 mg/m2, etoposide 100 mg/m2, and mesna uroprotection daily x 4 given every 28 days) in thirty six patients with intermediate or high-grade non-Hodgkin's lymphomas (NHL's). All patients had disease refractory to anthracycline-based chemotherapy and were ineligible for our dose intensive salvage chemotherapy program including autologous bone marrow transplant (ABMT). Twenty six men and 10 women aged 21-79 years (median 61) were given 100 courses of treatment in hospital. Twenty three patients had stage IV, 7 stage III and 6 stage II disease. Fourteen patients had bone marrow involvement and 11 had B symptoms. Thirty two patients had received only 1 previous chemotherapy regimen. After a follow-up of 1-70 months (median 7), 8 of the 34 (23%) patients evaluable for response had complete remission (CR) of their disease for 8-70+ months (med 24) and 15/34 (44%) partial remission (PR) for 2-55+ months (med 13), giving an overall response rate of 67% (23/34). Eight of the 36 patients are alive 34-70 months (median 48) after being enrolled on study, 6 of whom relapsed and responded to subsequent treatment. The estimate...Continue Reading

References

Jul 1, 1991·Hematological Oncology·I MagrathV Jain
Jan 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P E GossS Sutcliffe
Jan 1, 1989·Leukemia Research·E A StadtmauerR P Gale
Mar 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F CabanillasT Smith
Jul 1, 1993·Leukemia & Lymphoma·W R BezwodaS Ariad
Dec 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A P RapoportM A Tanner

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Citations

Feb 20, 1999·American Journal of Clinical Oncology·N HaimM Ben-Shahar

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