Dichlorobis(2-phenylazopyridine)ruthenium(II) complexes: characterisation, spectroscopic and structural properties of four isomers

Dalton Transactions : an International Journal of Inorganic Chemistry
Aldrik H VeldersAnthony L Spek

Abstract

The didentate ligand 2-phenylazopyridine (azpy) can--in theory--give rise to five different isomeric complexes of the type [Ru(azpy)2Cl2], of which three have been known since 1980. The molecular structures of the cis-dichlorobis(2-phenylazopyridine) ruthenium(II) complexes alpha-[Ru(azpy)2Cl2] and beta-[Ru(azpy)2Cl2](in which the coordinating pyridine nitrogen atoms are in mutually trans and cis positions, respectively, whilst the azo nitrogen atoms are in mutually cis positions) were unambiguously determined in the early 1980s. The third isomer, gamma-[Ru(azpy)2Cl2], has for two decades, erroneously, been assumed to be the all-trans isomer. In a recent communication we have proven that for this gamma isomer the chloride ions are indeed in a trans geometry, but the pyridine nitrogen and azo nitrogen atoms of the two azpy ligands are in mutually cis geometries. In this paper the isolation of a fourth isomer is presented, the hitherto unknown delta-[Ru(azpy)2Cl2]. The isomeric structure of delta-[Ru(azpy)2Cl2] has been determined by 1H-NMR spectroscopy and single-crystal X-ray diffraction analysis, and is the all-trans isomer. The bis(azpy)-ruthenium(II) isomers are of interest because of the pronounced cytotoxicity they exhibit...Continue Reading

References

Dec 26, 2001·Chemical Reviews·M J ClarkeD R Frasca
Apr 18, 2003·Journal of Medicinal Chemistry·Anna C G HotzeJan Reedijk

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Citations

Apr 1, 2011·Chemical Communications : Chem Comm·Vaishali VajpayeeKi-Whan Chi
Jul 18, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Aparajita MukherjeeSamaresh Bhattacharya
Sep 6, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Bryan A AlbaniClaudia Turro
Dec 18, 2007·European Journal of Medicinal Chemistry·Si Yan LiaoKang Cheng Zheng

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