Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

Frontiers in Behavioral Neuroscience
Brandon H ClineTatyana Strekalova

Abstract

Central insulin receptor-mediated signaling is attracting the growing attention of researchers because of rapidly accumulating evidence implicating it in the mechanisms of plasticity, stress response, and neuropsychiatric disorders including depression. Dicholine succinate (DS), a mitochondrial complex II substrate, was shown to enhance insulin-receptor mediated signaling in neurons and is regarded as a sensitizer of the neuronal insulin receptor. Compounds enhancing neuronal insulin receptor-mediated transmission exert an antidepressant-like effect in several pre-clinical paradigms of depression; similarly, such properties for DS were found with a stress-induced anhedonia model. Here, we additionally studied the effects of DS on several variables which were ameliorated by other insulin receptor sensitizers in mice. Pre-treatment with DS of chronically stressed C57BL6 mice rescued normal contextual fear conditioning, hippocampal gene expression of NMDA receptor subunit NR2A, the NR2A/NR2B ratio and increased REM sleep rebound after acute predation. In 18-month-old C57BL6 mice, a model of elderly depression, DS restored normal sucrose preference and activated the expression of neural plasticity factors in the hippocampus as show...Continue Reading

References

Apr 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A MaekawaY Hayashi
Jan 1, 1995·Advances in Neuroimmunology·R CespuglioB el Kafi
Jul 2, 1999·Journal of Sleep Research·J L ValatxD Bucchini
May 30, 2001·Molecular and Cellular Endocrinology·W Q Zhao, D L Alkon
Jul 5, 2001·Physiology & Behavior·P MeerloS Daan
Oct 3, 2002·The American Journal of Psychiatry·Thomas A MellmanBruce Nolan
Dec 24, 2002·BMC Neuroscience·Jonathan P WisorPaul Franken
Mar 5, 2003·Journal of Cell Science·Bradley W Doble, James R Woodgett
Jul 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tatyana StrekalovaPeter Gass
Feb 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janel M Boyce-Rustay, Andrew Holmes
Jun 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi ZhaoJuraj Culman
Aug 19, 2006·Progress in Neurobiology·Lars P van der HeideMarten P Smidt
Oct 24, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·S AliK Khunti
Mar 16, 2007·Journal of Alzheimer's Disease : JAD·Jay C StrumAllen Roses
Apr 4, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·S AsgharA Magnusson
May 1, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sangeeta R Kashyap, Ralph A Defronzo
Oct 19, 2007·PLoS Biology·Jason M WilliamsAurelio Galli
Nov 13, 2007·Physiology & Behavior·Paula Ayako TibaDeborah Suchecki
Feb 14, 2008·Journal of Atherosclerosis and Thrombosis·Masahiko IgarashiMakoto Tominaga
Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Dawn K ColettaChristopher P Jenkinson

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Citations

Apr 14, 2020·Cell Proliferation·Xiao Han ZouRan Ji Cui
Jul 13, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucile CapuronNathalie Castanon

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Methods Mentioned

BETA
dissection
PCR
tail
ELISA
chips
Chip
PCA
pharmacotherapy

Software Mentioned

GraphPad Prism
Partek
GS
Partek Genomics Suite
Somnologica
Gene Chip Operating System

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