Dichotic listening tests of functional brain asymmetry predict response to fluoxetine in depressed women and men

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Gerard E BruderFrederic M Quitkin

Abstract

Patients having a depressive disorder vary widely in their therapeutic responsiveness to a selective serotonin reuptake inhibitor (SSRI), but there are no clinical predictors of treatment outcome. Studies using dichotic listening, electrophysiologic and neuroimaging measures suggest that pretreatment differences among depressed patients in functional brain asymmetry are related to responsiveness to antidepressants. Two new studies replicate differences in dichotic listening asymmetry between fluoxetine responders and nonresponders, and demonstrate the importance of gender in this context. Right-handed outpatients who met DSM-IV criteria for major depression, dysthymia, or depression not otherwise specified were tested on dichotic fused-words and complex tones tests before completing 12 weeks of fluoxetine treatment. Perceptual asymmetry (PA) scores were compared for 75 patients (38 women) who responded to treatment and 39 patients (14 women) who were nonresponders. Normative data were also obtained for 101 healthy adults (61 women). Patients who responded to fluoxetine differed from nonresponders and healthy adults in favoring left- over right-hemisphere processing of dichotic stimuli, and this difference was dependent on gende...Continue Reading

Associated Clinical Trials

Feb 27, 2006·Jonathan W Stewart, M.DJonathan W Stewart, M.D

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Citations

Sep 15, 2006·Psychopharmacology·Erin B McClureDaniel S Pine
Jun 6, 2008·Integrative Psychological & Behavioral Science·Aaro Toomela
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