Dichotomous histopathological assessment of ductal carcinoma in situ of the breast results in substantial interobserver concordance

Histopathology
Mieke Van BockstalJo Van Dorpe

Abstract

Robust prognostic markers for ductal carcinoma in situ (DCIS) of the breast require high reproducibility and thus low interobserver variability. The aim of this study was to compare interobserver variability among 13 pathologists, in order to enable the identification of robust histopathological characteristics. One representative haematoxylin and eosin-stained slide was selected for 153 DCIS cases. All pathologists independently assessed nuclear grade, intraductal calcifications, necrosis, solid growth, stromal changes, stromal inflammation, and apocrine differentiation. All characteristics were assessed categorically. Krippendorff's alpha was calculated to assess overall interobserver concordance. Cohen's kappa was calculated for every observer duo to further explore interobserver variability. The highest concordance was observed for necrosis, calcifications, and stromal inflammation. Assessment of solid growth, nuclear grade and stromal changes resulted in lower concordance. Poor concordance was observed for apocrine differentiation. Kappa values for each observer duo identified the 'ideal' cut-off for dichotomisation of multicategory variables. For instance, concordance was higher for 'non-high versus high' nuclear grade th...Continue Reading

References

Sep 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C W ElstonB Zafrani
Sep 26, 2000·Journal of Clinical Pathology·A G Douglas-JonesS Williams
May 8, 2002·American Journal of Clinical Pathology·J R Durham, R E Fechner
Oct 31, 2006·Breast Cancer Research : BCR·Juliane HannemannMarc J van de Vijver
Nov 7, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eileen RakovitchLawrence Paszat
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rosemary L BalleinePaul S Meltzer
May 27, 2010·Histopathology·Maria A Lopez-GarciaJorge S Reis-Filho
Jun 3, 2010·British Journal of Cancer·S E PinderUNKNOWN UK Coordinating Committee on Cancer Research (UKCCCR) Ductal Carcinoma In Situ (DCIS) Working Party
Jul 29, 2010·Pathology, Research and Practice·Fernando SchuhMaria Isabel Albano Edelweiss
May 3, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rohit K JainSunil Badve
May 4, 2013·Journal of the National Cancer Institute·Lawrence J SolinSunil Badve
Jun 30, 2014·Virchows Archiv : an International Journal of Pathology·Mieke Van BockstalLouis Libbrecht
Dec 3, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·A FrancisD Rea
Mar 18, 2015·JAMA : the Journal of the American Medical Association·Joann G ElmoreDonald L Weaver
May 31, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lotte E ElshofJelle Wesseling
Jan 16, 2016·Histopathology·Jia-Min B PangStephen B Fox
Mar 31, 2016·Histopathology·Mieke Van BockstalKathleen Lambein
May 24, 2016·The Breast : Official Journal of the European Society of Mastology·S C DoebarC H M van Deurzen
Nov 20, 2016·Journal of Clinical Pathology·Joe YeongJabed Iqbal
Apr 21, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G PruneriG Viale
May 24, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tracy OnegaJoann G Elmore
Jun 15, 2017·The American Journal of Surgical Pathology·Leslie W Dalton, Thomas A Gerds
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Van BockstalS Pinder
Nov 8, 2017·Frontiers in Oncology·Kylie L Gorringe, Stephen B Fox
Mar 22, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael S TossEmad A Rakha
Jul 13, 2018·Histopathology·Emad A RakhaLes W Dalton

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Citations

Apr 25, 2019·International Journal of Cancer. Journal International Du Cancer·Mieke R Van BockstalCarolien H M van Deurzen
Nov 27, 2019·American Journal of Clinical Pathology·Sarah A AlghamdiCarmen R Gomez-Fernandez
Sep 20, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hélène DanoMieke R Van Bockstal
Jun 23, 2020·American Journal of Clinical Pathology·Mieke R Van BockstalChristine Galant
Aug 1, 2020·Breast Cancer Research and Treatment·Emma J GroenUNKNOWN Grand Challenge PRECISION consortium
Nov 30, 2019·Pathology Oncology Research : POR·Gábor Cserni, Anita Sejben
Apr 27, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindy L VisserJelle Wesseling
Jan 28, 2021·Virchows Archiv : an International Journal of Pathology·Claudia Stanciu-PopMieke R Van Bockstal
Nov 18, 2020·British Journal of Cancer·Abeer M ShaabanUNKNOWN Sloane Project Steering Committee
Feb 24, 2021·The Journal of Pathology. Clinical Research·Maartje van SeijenUNKNOWN Grand Challenge PRECISION consortium.
Jul 27, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S LoiR Salgado
Jan 26, 2022·Journal of Mammary Gland Biology and Neoplasia·Marie Colombe AgahozoCarolien H M van Deurzen

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