Dichroism-sensitive photoacoustic computed tomography

Optica
Yuan QuLihong V Wang

Abstract

Photoacoustic computed tomography (PACT), a fast-developing modality for deep tissue imaging, images the spatial distribution of optical absorption. PACT usually treats the absorption coefficient as a scalar. However, the absorption coefficients of many biological tissues exhibit an anisotropic property, known as dichroism or diattenuation, which depends on molecular conformation and structural alignment. Here we present a novel imaging method called dichroism-sensitive PACT (DS-PACT), which measures both the amplitude of tissue's dichroism and the orientation of the optic axis of uniaxial dichroic tissue. By modulating the polarization of linearly polarized light and measuring the alternating signals through lock-in detection, DS-PACT can boost dichroic signals from biological tissues. To validate the proposed approach, we experimentally demonstrated the performance of DS-PACT by imaging plastic polarizers and ex vivo bovine tendons deep inside scattering media. We successfully detected the orientation of the optic axis of uniaxial dichroic materials, even at a depth of 4.5 transport mean free paths. We anticipate that the proposed method will extend the capability of PACT to imaging tissue absorption anisotropy.

References

Aug 15, 2002·Journal of Biomedical Optics·Vanitha SankaranDuncan J Maitland
Feb 15, 2005·IEEE Transactions on Medical Imaging·Mark A AnastasioLihong V Wang
Apr 5, 2008·Journal of Cell Science·Minhui Lee, Valeri Vasioukhin
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gerard MarriottYuling Yan
Oct 8, 2014·Advances in Cancer Research·Marie-France PenetZaver M Bhujwalla

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Citations

Apr 11, 2019·Journal of Biomedical Optics·Paul Kumar Upputuri, Manojit Pramanik
Feb 7, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Paul Kumar Upputuri, Manojit Pramanik

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