Diclofenac for pain associated with intravitreal injections: a prospective, randomized, placebo-controlled study

Clinical & Experimental Ophthalmology
Olga E MakriConstantine D Georgakopoulos

Abstract

Intravitreal injections (IVI) are often painful. To evaluate the analgesic effect of diclofenac in patients undergoing IVI. Single-centre, prospective, randomized, triple-arm, placebo-controlled, interventional study in the University Hospital of Patras. Seventy-four patients. Group 1 (n = 25) received topical diclofenac 45 min before IVI, Group 2 (n = 25) received oral diclofenac 4 h before IVI and topical diclofenac while Group 3 (n = 24) received placebo before IVI. Using the short form of the McGill Pain Questionnaire (SF-MPQ), pain intensity was assessed with the visual analogue scale (VAS), the main component of the SF-MPQ and the Present Pain Intensity (PPI) scores immediately and 6 h post-IVI. The VAS pain score immediately post-IVI. Immediately post-IVI, patients in Group 2 reported significantly lower VAS pain scores compared to placebo while no statistically significant difference was found between patients that received topical diclofenac and placebo. Six hours post-IVI, patients in both treatment groups reported significant lower VAS pain scores compared to placebo. The scores of the main component of the SF-MPQ were significantly lower in patients of treatment groups compared to placebo at both time-points. Finall...Continue Reading

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Citations

Jan 29, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Constantine D GeorgakopoulosOlga E Makri

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