Diclofenac in municipal wastewater treatment plant: quantification using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry approach in comparison with an established liquid chromatography-electrospray ionization-tandem mass spectrometry method

Journal of Chromatography. a
Linson LonappanJosé R Valero

Abstract

Diclofenac (DCF), a prevalent non-steroidal anti-inflammatory drug (NSAID) is often detected in wastewater and surface water. Analysis of the pharmaceuticals in complex matrices is often laden with challenges. In this study a reliable, rapid and sensitive method based on laser diode thermal desorption/atmospheric pressure chemical ionization (LDTD/APCI) coupled with tandem mass spectrometry (MS/MS) has been developed for the quantification of DCF in wastewater and wastewater sludge. An established conventional LC-ESI-MS/MS (liquid chromatography-electrospray ionization-tandem mass spectrometry) method was compared with LDTD-APCI-MS/MS approach. The newly developed LDTD-APCI-MS/MS method reduced the analysis time to 12s in lieu of 12min for LC-ESI-MS/MS method. The method detection limits for LDTD-APCI-MS/MS method were found to be 270ngL(-1) (LOD) and 1000ngL(-1) (LOQ). Furthermore, two extraction procedures, ultrasonic assisted extraction (USE) and accelerated solvent extraction (ASE) for the extraction of DCF from wastewater sludge were compared and ASE with 95.6±7% recovery was effective over USE with 86±4% recovery. The fate and partitioning of DCF in wastewater (WW) and wastewater sludge (WWS) in wastewater treatment plant...Continue Reading

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Citations

Oct 23, 2016·Environment International·Linson LonappanRao Y Surampalli
Nov 30, 2020·Journal of Pharmaceutical and Biomedical Analysis·Giovanni LuongoArmando Zarrelli
Oct 30, 2021·The Science of the Total Environment·Srdana KolakovicAdrian Oehmen

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