Diclofenac potassium for oral solution (CAMBIA(®)) in the acute management of a migraine attack: clinical evidence and practical experience

Therapeutic Advances in Neurological Disorders
Shivang Joshi, Alan M Rapoport

Abstract

Migraine headache affects about 12% of Western populations and is the third most common disease worldwide (sixth in terms of disability). In 1993, triptans were introduced in the United States as a new treatment for managing migraine attacks, but their use is limited by lack of response and safety concerns in some patients. Treatment options for patients with migraine who fail or cannot tolerate triptans include switching to another medication or adding an adjunctive medication. Desirable characteristics reported by patients for acute treatment of migraine attacks include complete pain relief, fast onset of action, and no pain recurrence. Diclofenac is a nonsteroidal anti-inflammatory medication that has been established as effective for acute treatment of migraine by the American Headache Society based on available evidence. Diclofenac potassium for oral solution is rapidly absorbed, achieving maximal plasma concentrations in 15 min, which coincides with a rapid onset of effect. In a comparison of diclofenac potassium for oral solution with diclofenac potassium tablets, the solution achieved a significant reduction in headache intensity beginning at 15 min compared with 60 min for the tablet. Across randomized clinical trials,...Continue Reading

References

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Oct 24, 2014·Annual Review of Pharmacology and Toxicology·Andrew F Russo
Nov 12, 2015·BMC Medicine·Dimos D Mitsikostas, Alan M Rapoport

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Citations

Nov 27, 2018·Expert Opinion on Pharmacotherapy·Paolo Martelletti, Maria Adele Giamberardino
Jun 7, 2018·Pain and Therapy·Fabiola AtzeniPiercarlo Sarzi-Puttini

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