Diclofenac sodium loaded-cellulose acetate butyrate: effect of processing variables on microparticles properties, drug release kinetics and ulcerogenic activity

Journal of Microencapsulation
Nahla S Barakat, Amany A E Ahmad

Abstract

The aim of this study was to develop and characterize diclofenac sodium loaded-cellulose acetate butyrate microparticles in order to obtain a controlled-release system. The influence of the type of polymer, the volume and composition of the internal phase, drug loading, surfactant concentration and additive added on microparticles characteristics (particle size, encapsulation efficiency, surface morphology and in vitro release profiles) was studied to optimize the microparticles system. The resultant microparticles were evaluated for the recovery, average particle size, drug loading and incorporation efficiency. The microparticles exhibited good flowing nature and compressibility index when compared to pure drug. Dissolution rate of diclofenac sodium in phosphate buffer (pH 6.8) increased with increases in initial drug loading, surfactant concentration and addition of alcohol as co-solvent but decreased with increases in the concentration of additives such as Gantrez AN or Eudragit S100 in the internal phase. The dissolution data showed a Higuchi diffusion pattern for most of the formulations. About 56-81% reduction in ulcerogenic activity was observed with microparticles containing Eudragit S100 17-25%, based on total polymer ...Continue Reading

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Citations

Dec 18, 2013·Archives of Pharmacal Research·Ki Hyun KimSeong Hoon Jeong
Mar 26, 2009·AAPS PharmSciTech·Renata P RaffinSilvia S Guterres
Oct 12, 2010·AAPS PharmSciTech·Annalisa DalmoroMatteo d'Amore
Oct 19, 2011·AAPS PharmSciTech·Martina BajerováRuta Masteiková
Jun 3, 2010·Journal of Microencapsulation·S MadhusudhanP K Manna
Oct 7, 2008·Colloids and Surfaces. B, Biointerfaces·Maria Letizia MancaSophia G Antimisiaris
Sep 28, 2015·International Journal of Pharmaceutics·Gennara CavallaroAnnalisa Dalmoro
Jan 31, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Annalisa DalmoroMatteo d'Amore
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Tapan Kumar GiriDulal Krishna Tripathi
Jun 15, 2017·Pharmaceutical Development and Technology·Hannlie HammanJan Harm Steenekamp
Jan 26, 2020·Drug Delivery and Translational Research·Shabnam AmanatArdeshir Talebi

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