Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Vinasan Naidoo, G E Swan

Abstract

Diclofenac (DF), a non-steroidal anti-inflammatory drug (NSAID), is largely regarded as one of the most devastating environmental toxicant in recent times, after accidental exposure via their food-chain lead to massive mortalities in three vulture species on the Asian subcontinent. Although the use of diclofenac was recently banned on the Indian subcontinent, following the favourable safety profile of meloxicam, its mechanism of toxicity remains unknown. In an attempt to establish this mechanism, we test three hypotheses using models established from either the domestic chicken (Gallus domesticus) or the African White-backed vulture (Gyps africanus). We demonstrate that both DF and meloxicam are toxic to renal tubular epithelial (RTE) cells following 12 h of exposure, due to an increase in production of reactive oxygen species (ROS), which could be temporarily ameliorated by pre-incubation with uric acid (UA). When cultures were incubated with either drug for only 2 h, meloxicam showed no toxicity in contrast to diclofenac. In both cases no increase in ROS production was evident. In addition, diclofenac decreased the transport of uric acid, by interfering with the p-amino-hippuric acid (PAH) channel. We conclude that vulture su...Continue Reading

References

Nov 20, 1986·Journal of Immunological Methods·D Gerlier, N Thomasset
Jan 1, 1983·Cell and Tissue Research·J L Morris, I L Gibbins
May 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·D JungbluthE Simon
Jun 1, 1993·Free Radical Biology & Medicine·B F Becker
Aug 15, 2000·Journal of Ethnopharmacology·L OrfilaF Arvelo
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Rajiv Agarwal
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Suparat KhamdangHitoshi Endou
Dec 11, 2002·Kidney International·Kimiyoshi IchidaHitoshi Endou
Jun 5, 2003·Acta Ophthalmologica Scandinavica·Anders HessellundToke Bek
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Mohammed A RafeyRuth G Abramson
Mar 1, 1960·The American Journal of Physiology·L BERGERA B GUTMAN
Nov 12, 2003·Biochemical Pharmacology·M José Gómez-LechónRamiro Jover
Jan 28, 2004·Nature·J Lindsay OaksAleem Ahmed Khan
Apr 2, 2005·Proceedings. Biological Sciences·Susanne ShultzVibhu Prakash
Sep 29, 2005·Clinical and Experimental Nephrology·Atsushi Enomoto, Hitoshi Endou
Nov 1, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Keiichi ShimamuraKenji Kitamura
Nov 8, 2005·The Journal of Experimental Biology·Paul L DudasJ Larry Renfro
Jan 27, 2006·PLoS Biology·Gerry SwanKerri Wolter
May 24, 2006·Rheumatic Diseases Clinics of North America·David B MountKambiz Zandi-Nejad
Aug 8, 2006·Biochemical and Biophysical Research Communications·Lin Eng NgKim Ping Wong
Dec 7, 2006·Biology Letters·Gerry E SwanKerri Wolter
Mar 31, 2007·Physiological Measurement·Anikó SomogyiGéza Nagy
Mar 1, 2008·Journal of Veterinary Pharmacology and Therapeutics·V NaidooG E Swan
Mar 8, 2008·Biochemical and Biophysical Research Communications·Lin Eng NgKim Ping Wong
Nov 1, 2007·Environmental Toxicology and Pharmacology·V NaidooG Swan

❮ Previous
Next ❯

Citations

Feb 18, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Teresa L Lightfoot
Jun 24, 2009·Regulatory Toxicology and Pharmacology : RTP·V NaidooN Duncan
May 7, 2016·Nature Reviews. Endocrinology·David M KristensenBernard Jégou
Oct 23, 2016·Environment International·Linson LonappanRao Y Surampalli
Dec 4, 2013·Infection Ecology & Epidemiology·Md Saiful IslamStephen P Luby
Nov 16, 2016·Anesthesiology and Pain Medicine·Maryam SoleimanpourSeyed Moayed Alavian
Jun 24, 2017·Journal of Avian Medicine and Surgery·Noémie M SummaGuy Fitzgerald
Feb 9, 2017·Ecotoxicology and Environmental Safety·Izonete Cristina GuiloskiHelena Cristina Silva de Assis
Feb 11, 2020·Environmental Science & Technology·Qiuguo FuJuliane Hollender
Dec 24, 2020·Journal of Avian Medicine and Surgery·Molly D HorganRebecca S Duerr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.