Dictyostelium discoideum chemotaxis: threshold for directed motion

European Journal of Cell Biology
Loling SongEberhard Bodenschatz

Abstract

The chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3',5'-monophosphate (cAMP) was studied using microfluidic devices. In shallow gradients of less than 10(-3) nM/microm, the cells showed no directional response and exhibited a constant basal motility. In steeper gradients, cells moved up the gradient on average. The chemotactic speed and the motility increased with increasing steepness up to a plateau at around 10(-1) nM/microm. In very steep gradients, above 10 nM/microm, the cells lost directionality and the motility returned to the sub-threshold level. In the regime of optimal response the difference in receptor occupancy at the front and back of the cell is estimated to be only about 100 molecules.

References

Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J M MatoT M Konijn
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P J Van HaastertR Van Driel
Nov 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J E Cutler, J J Munoz
Sep 1, 1984·The Journal of Cell Biology·B Varnum, D R Soll
Mar 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J C Dallon, H G Othmer
Apr 30, 1999·Science·C A Parent, P N Devreotes
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·D T ChiuG M Whitesides
Mar 9, 2000·Seminars in Cell & Developmental Biology·M Meima, P Schaap
Jul 13, 2000·Current Opinion in Genetics & Development·R A Firtel, R Meili
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Meinhardt, A Gierer
Aug 18, 2001·Biophysical Journal·M Postma, P J Van Haastert
Apr 16, 2002·The International Journal of Biochemistry & Cell Biology·Gareth E JonesAdrian Thrasher
Aug 15, 2002·Current Biology : CB·Dirk DormannCornelis J Weijer
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roland Thar, Michael Kuhl
Jun 7, 2003·Science·Alan R Kimmel, Carole A Parent
Jul 1, 1964·Archives of Biochemistry and Biophysics·W J BOWEN, H L MARTIN
Dec 10, 2003·Current Opinion in Microbiology·Hazel P Williams, Adrian J Harwood
Jan 8, 2004·EMBO Reports·Marten PostmaPeter J M Van Haastert
Jul 3, 2004·Nature Reviews. Molecular Cell Biology·Rex L Chisholm, Richard A Firtel
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Peter J M Van Haastert, Peter N Devreotes
Sep 24, 2004·Experimental Cell Research·Shur-Jen WangNoo Li Jeon
Jul 21, 2007·Experimental Cell Research·Daniel S Rhoads, Jun-Lin Guan

❮ Previous
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Citations

Dec 23, 2011·Annals of Biomedical Engineering·Beum Jun Kim, Mingming Wu
Dec 4, 2013·Comptes rendus biologies·Rui Dilão, Marcus J B Hauser
Oct 1, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Monica SkogeWouter-Jan Rappel
Oct 16, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Dawit JowharChristopher Janetopoulos
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wouter-Jan Rappel, Herbert Levine
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Danny FullerWilliam F Loomis
Feb 4, 2010·Cardiovascular Research·Connie H Y WongPaul Kubes
Sep 13, 2013·Journal of the Royal Society, Interface·Igor SegotaCarl Franck
Apr 11, 2013·The European Physical Journal. E, Soft Matter·Tetsuya HiraiwaTatsuo Shibata
May 11, 2010·Annual Review of Biomedical Engineering·Daniel Irimia
May 10, 2011·PLoS Computational Biology·Alexandra Jilkine, Leah Edelstein-Keshet
Jul 9, 2011·PLoS Computational Biology·Inbal HechtWouter-Jan Rappel
Jun 28, 2012·PLoS Computational Biology·William R HolmesLeah Edelstein-Keshet
Aug 11, 2011·PloS One·Inbal HechtEshel Ben-Jacob
Jun 5, 2012·PloS One·Gabriel AmselemCarsten Beta
Sep 7, 2012·PloS One·William F LoomisWouter-Jan Rappel
Dec 24, 2013·Physics Today·Herbert Levine, Wouter-Jan Rappel
Nov 1, 2011·Journal of Laser Applications·L CostaC Janetopoulos
Aug 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paul HerzmarkHenry R Bourne
Jun 7, 2011·Journal of Statistical Physics·Bo HuWouter-Jan Rappel
Feb 3, 2016·Molecular Pharmaceutics·Julien Varennes, Andrew Mugler
Jan 20, 2016·International Journal of Molecular Sciences·Marjon E KampArjan Kortholt
Jan 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrew MuglerIlya Nemenman
Sep 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Monica SkogeWouter-Jan Rappel
Aug 7, 2010·Journal of Computational Physics·Charles W Wolgemuth, Mark Zajac
Feb 14, 2009·Protist·M Berenice DuranDerrick Brazill
Jul 8, 2008·Bio Systems·Manolya EyiyurekliDavid E Breen
Jan 1, 2009·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Wouter-Jan Rappel, William F Loomis
Aug 11, 2006·The EMBO Journal·Dirk Dormann, Cornelis J Weijer
Jun 13, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Changji Shi, Pablo A Iglesias
May 20, 2009·Biophysical Journal·Daniel IrimiaMehmet Toner
Apr 10, 2007·Biophysical Journal·Masahiro Ueda, Tatsuo Shibata
Jun 4, 2013·Current Opinion in Cell Biology·Pere Roca-CusachsXavier Trepat
Jun 20, 2015·Nature Communications·Brendan A BicknellGeoffrey J Goodhill
Mar 7, 2012·Cell Cycle·Wouter-Jan Rappel, Richard A Firtel
Aug 11, 2016·Biophysical Journal·Julien VarennesAndrew Mugler
Oct 6, 2016·PloS One·Markela IboZachary R Gagnon
Nov 4, 2016·Scientific Reports·Honda NaokiShin Ishii
Feb 23, 2007·The Journal of Chemical Physics·David J EarlJ M Yeomans
Apr 25, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Meghaan M FerreiraSarah C Heilshorn

❮ Previous
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