Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity

Journal of Neurochemistry
Masami IshidoMasatoshi Morita

Abstract

Endocrine disruptors possibly exert effects on neuronal functions leading, in particular, to behavioural alterations. In this study, we examined the effects of dicyclohexylphthalate (DCHP), an endocrine disruptor, on rat behavioural and cellular responses. Single intracisternal administration of DCHP (0.87-87 nmol) into 5-day-old male Wistar rats caused significant hyperactivity at 4-5 weeks of age. It was about 1.4-fold more active in the nocturnal phase after administration of 87 nmol of DCHP than control rats (p < 0.001). The response had a tendency to be dose-dependent. Based on DNA macoarray analyses, DCHP down-regulated the levels of gene expression of the dopamine D4 receptor at 4 weeks old in both the midbrain and the striatum, and the dopamine transporter in the midbrain at 8 weeks old 1.7- to 2-fold. The gene expression of several subtypes of glutamate receptors was facilitated in the striatum at 4 weeks old and in the midbrain at 8 weeks old. Some normalization and/or compensatory changes seemed to occur in gene expression of GABA or glycine transmission. Furthermore, DCHP abolished immunoreactivity of tyrosine hydroxylase in the substantia nigra at 8 weeks of age, where TUNEL-positive cells were seen. We conclude th...Continue Reading

References

Apr 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R W TylC A Kimmel
Sep 12, 1996·The New England Journal of Medicine·J L Jacobson, S W Jacobson
Dec 31, 1997·Brain Research. Brain Research Protocols·Y MasuoJ Noguchi
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M JiangL Birnbaumer
Jun 18, 1998·Toxicological Sciences : an Official Journal of the Society of Toxicology·E MylchreestP M Foster
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·C L ParksM Toth
Sep 25, 1998·Journal of Toxicology and Environmental Health. Part a·M IshidoT Suzuki
Mar 11, 1999·The New England Journal of Medicine·J EliaJ L Rapoport
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·J C CortonA Stauber
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·D J GerberS Tonegawa
Jan 5, 2002·Neuron·U Frith
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Eugen DavidsRoss J Baldessarini
Jun 4, 2002·Nature Reviews. Neuroscience·Christian Behl
Apr 14, 2004·Journal of Neuroscience Research·Masami IshidoMasatoshi Morita

❮ Previous
Next ❯

Citations

Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Yoshinori Masuo, Masami Ishido
Mar 3, 2010·Environmental Health Perspectives·Soo-Churl ChoHyo-Won Kim
Aug 9, 2013·International Journal of Environmental Research and Public Health·Ilona QuaakMargot Van de Bor
Aug 23, 2011·Neurotoxicology and Teratology·Kimberly YoltonJane Khoury
Nov 11, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Masami Ishido, Junko Suzuki
Sep 15, 2009·Biological Psychiatry·Bung-Nyun KimYun-Chul Hong
Sep 3, 2013·Journal of Neuroscience Research·Manorama PatriBirendra Nath Mallick
Jun 1, 2015·Seminars in Cell & Developmental Biology·Frances XinMarisa S Bartolomei
Feb 18, 2014·General and Comparative Endocrinology·Martha León-OleaVance L Trudeau
Oct 23, 2012·International Journal of Occupational Medicine and Environmental Health·Kinga PolańskaWojciech Hanke
May 22, 2018·Journal of Attention Disorders·Johanna Inhyang KimBung-Nyun Kim
Jul 31, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ji-Cai FanShu-Ting Wang
Jan 15, 2014·The Journal of Toxicological Sciences·Masami Ishido, Junko Suzuki
Dec 7, 2018·Environmental Health : a Global Access Science Source·Hyeong-Moo ShinIrva Hertz-Picciotto
Jan 19, 2021·Pharmacological Reports : PR·Henrieta HlisníkováAlexander Sirotkin
Jan 27, 2021·Environmental Science and Pollution Research International·Anil YirunBelma Kocer-Gumusel
Feb 19, 2021·Journal of Applied Physiology·Toshinori YoshiharaHisashi Naito
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshinori MasuoKazuo Koike

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.