Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?

Trends in Microbiology
A CovacciR Rappuoli

Abstract

Strains of Helicobacter pylori from patients with peptic ulcer disease and gastric cancer contain a 40-kb fragment of DNA that is not present in isolates from carriers with asymptomatic infections. The discovery of the cag pathogenicity island suggests that virulence has evolved by quantum leaps through the inheritance of one or more DNA insertions.

References

Nov 1, 1995·Infection and Immunity·E S DrazekR L Warren
May 1, 1994·The Journal of Experimental Medicine·J L TelfordZ Xiang
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·E D SegalL S Tompkins
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E SheaD W Holden
Feb 1, 1996·Trends in Microbiology·S C WinansP J Christie
Nov 29, 1996·Cell·E A Groisman, H Ochman
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S CensiniA Covacci
Oct 1, 1996·Emerging Infectious Diseases·J J Mecsas, E J Strauss

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Citations

Oct 28, 1998·Molecular Aspects of Medicine·G Del GiudiceR Rappuoli
Oct 2, 2001·Archives of Medical Research·M Mazari-HiriartA Cravioto
Aug 1, 1997·Current Opinion in Immunology·J L TelfordP Chiara
Jun 30, 2000·Current Opinion in Cell Biology·D G Thanassi, S J Hultgren
Jun 20, 2003·Microbes and Infection·Ann-Mari Svennerholm, Marianne Quiding-Järbrink
Feb 15, 2001·Current Opinion in Microbiology·S CensiniA Covacci
Mar 6, 1999·Current Opinion in Microbiology·S Karlin
Mar 6, 1999·Current Opinion in Microbiology·A Covacci, R Rappuoli
Feb 27, 1999·Current Opinion in Microbiology·D L Burns
Nov 1, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B OrsiniC Surrenti
Jun 6, 2002·Alimentary Pharmacology & Therapeutics·D VairaM Miglioli
Jun 26, 2001·Symposium Series·J G Kusters, E J Kuipers
Oct 9, 2002·Cellular Microbiology·Manuel R AmievaStanley Falkow
Nov 8, 2001·Journal of Pediatric Gastroenterology and Nutrition·G A RochaA S Teles de Carvalho
Aug 31, 2000·Applied and Environmental Microbiology·S ChakrabortyG B Nair
Jan 9, 2003·Journal of Clinical Microbiology·Andreia Maria Camargos RochaDulciene Maria Magalhães Queiroz
Aug 21, 2001·Gut·V J Warburton-TimmsC A McNulty
Feb 3, 1999·Annual Review of Genetics·S KarlinJ Mrázek
Sep 24, 2013·BMC Gastroenterology·Danielle Queiroz CalcagnoRommel Rodriguez Burbano
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J T Sullivan, C W Ronson
Feb 14, 2006·The American Naturalist·Xuhua Xia, Gareth Palidwor
Jun 5, 2015·Cellular Microbiology·Jyoti Prasad MishraMarkus Stein
Jul 10, 2009·International Journal of Cancer. Journal International Du Cancer·Motohiro MiuraMasanori Hatakeyama
Aug 26, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A I ShararaE M Kfoury Baz
Feb 14, 2006·Pathologie-biologie·J-P LavigneD O'Callaghan
Oct 28, 1999·American Heart Journal·J G Kusters, E J Kuipers
Jan 25, 2003·Journal of Internal Medicine·B BjörkholmO Nyrén
May 12, 2007·Helicobacter·William J SnellingPaul W O'Toole
Nov 5, 1999·Annual Review of Microbiology·Z Ge, D E Taylor
Oct 23, 1997·Chemistry & Biology·C Stephens, L Shapiro
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Van Eldere
Nov 5, 2003·Memórias do Instituto Oswaldo Cruz·Diana OrtizJacinto Convit

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