PMID: 7518658Aug 15, 1994Paper

Didanosine resistance in HIV-infected patients switched from zidovudine to didanosine monotherapy

Annals of Internal Medicine
M J KozalT C Merigan

Abstract

To determine the frequency and pattern of development of specific drug resistance mutations for human immunodeficiency virus (HIV) reverse transcriptase in patients switched from zidovudine to didanosine therapy and to examine the relation of the didanosine resistance mutation at codon 74 of the HIV reverse-transcriptase gene to CD4+ T-cell changes and virus burden. Retrospective analysis of all patients enrolled at Stanford University in protocols where patients were switched from zidovudine to didanosine monotherapy. A university hospital. 64 patients infected with HIV who were switched from zidovudine to didanosine monotherapy. Patients had the acquired immunodeficiency syndrome (AIDS), AIDS-related complex, or were asymptomatic (mean [+/- SD] starting CD4+ T-cell count of 129 +/- 88 cells/mm3). Serial serum specimens were tested for the didanosine resistance mutation at codon 74 of the HIV reverse-transcriptase gene and for a zidovudine resistance mutation at codon 215 using selective polymerase chain reactions (PCR). Serum HIV RNA levels were determined by quantitative PCR. CD4+ T-cell counts were determined at serial time points. By 24 weeks of didanosine therapy, the proportion of patients with the didanosine resistance ...Continue Reading

Citations

Nov 30, 2000·Current Infectious Disease Reports·G J Hanna, R T D'Aquila
Nov 14, 1998·Disease-a-month : DM·H W HorowitzG P Wormser
Jun 9, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J G García-Lerma, W Heneine
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