Didecarboxylative Iron-Catalyzed Bidirectional Aldolization towards Diversity-Oriented Ketodiol Synthesis

Chemistry : a European Journal
A Quintard, J Rodriguez

Abstract

1,3-Acetonedicarboxylic acid was selectively activated by Fe(acac)3 , providing a synthetic platform for rapid synthesis of keto-3,3'-diols. The bidirectional aldol reaction was efficient for challenging aliphatic aldehydes, providing a rapid route to potentially bioactive complex structures.

References

Apr 6, 2000·The Journal of Organic Chemistry·R Chênevert, Y S Rose
Nov 1, 1996·The Journal of Organic Chemistry·Michelle M. Claffey, Clayton H. Heathcock
Oct 25, 2001·The Journal of Organic Chemistry·Michelle M. ClaffeyClayton H. Heathcock
Mar 6, 2003·Journal of the American Chemical Society·Gojko LalicMatthew D Shair
May 19, 2005·Journal of the American Chemical Society·Derek MagdziakMatthew D Shair
Jun 9, 2005·Journal of the American Chemical Society·Thomas R Hoye, Troy D Ryba
Jun 25, 2005·Organic & Biomolecular Chemistry·Ian PatersonDebra J Wallace
Sep 28, 2005·Chemical Society Reviews·Ari M P Koskinen, Kaisa Karisalmi
Oct 20, 2006·Angewandte Chemie·Mark J Mitton-FryTarek Sammakia
Nov 15, 2006·Angewandte Chemie·Bernd Schetter, Rainer Mahrwald
Nov 4, 2008·Bioorganic & Medicinal Chemistry·Berin A BoughtonCraig A Hutton
Mar 17, 2010·Angewandte Chemie·Brian J Albert, Hisashi Yamamoto
Mar 9, 2011·Organic Letters·Kerstin Rohr, Rainer Mahrwald
Feb 19, 2013·Angewandte Chemie·Yasushi ShimodaMakoto Nakajima
Nov 26, 2013·Organic & Biomolecular Chemistry·Shuichi Nakamura
Oct 28, 2014·Chemistry : a European Journal·Guillem ValeroAlbert Moyano
Mar 10, 2015·Chemical Reviews·Ingmar Bauer, Hans-Joachim Knölker
May 15, 2015·Chemical Communications : Chem Comm·A Quintard, J Rodriguez

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Citations

Jan 25, 2020·Organic & Biomolecular Chemistry·Céline SperandioAdrien Quintard
Feb 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Hao ZhouQi-Xiang Guo
Mar 23, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Adrien Quintard
Dec 29, 2018·Organic Letters·Adrien Quintard, Jean Rodriguez

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