Dielectric properties for non-invasive detection of normal, benign, and malignant breast tissues using microwave theories

Thoracic Cancer
Yiou Cheng, Minghuan Fu

Abstract

Despite the high incidence of breast cancer worldwide, methods for early non-invasive diagnosis and sensitive and specific prognostic evaluation remain difficult. In this study, we investigated microwave parameters as a potential non-invasive approach to detect breast cancer. Samples of freshly excised breast tissues (n = 509) from 98 patients were identified as normal, benign tumor, or malignant cancer via histology. Further samples were prepared and the microwave effective dielectric permittivity and effective conductivity were measured every 0.0375 GHz from 0.5 GHz to 8 GHz. These parameters were compared among the breast tissue types. The effective relative permittivity and effective conductivity at each frequency was significantly higher in breast cancer tissues compared with benign tumors, which in turn was significantly higher than in normal breast tissue. The standard deviation of each parameter was narrowest at ~2.5 GHz in both normal and malignant breast tissues. The effective dielectric permittivity and effective conductivity, measured via microwave technology, could differentiate breast cancer from normal and benign tumor tissues.

References

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Citations

May 24, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·H N MayrovitzD A Altman
Dec 31, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ricardo RivasPeter M van Ooijen
Feb 6, 2020·Medical Physics·Raquel C ConceiçãoStephen Pistorius
Apr 26, 2020·Sensors·Maged A AldhaeebiOmar M Ramahi
Sep 1, 2020·Physical and Engineering Sciences in Medicine·Emine Avşar Aydın, Ahmet Refah Torun
Aug 24, 2018·Scientific Reports·Maged A AldhaeebiOmar M Ramahi
Sep 12, 2018·Diagnostics·Tomas RydholmPaul M Meaney
Dec 29, 2020·Electromagnetic Biology and Medicine·Shadeeb Hossain
Aug 10, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Mamdouh M ShawkiSanaa Shawki

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