PMID: 9421142Jan 8, 1998Paper

Diencephalic projection to reticulospinal neurons involved in the initiation of locomotion in adult lampreys Lampetra fluviatilis

The Journal of Comparative Neurology
A El ManiraSten Grillner

Abstract

Morphological and electrophysiological techniques were used to characterize a diencephalic projection from the ventral thalamus to reticulospinal neurons and its role in initiating rhythmic locomotor activity in the spinal cord of adult lampreys (Lampetra fluviatilis). Injection of fluorescein-coupled dextran amine (FDA) into the rhombencephalic reticular nuclei labeled neurons in the ventral thalamus region on both the ipsilateral side and the contralateral side. Injection of FDA into the ventral thalamus labeled axonal projections in all reticular nuclei, but no direct projections were found to the spinal cord. Extracellular stimulation of the ventral thalamus elicited monosynaptic excitatory postsynaptic potentials (EPSPs), polysynaptic EPSPs, and inhibitory postsynaptic potentials (IPSPs) in reticulospinal neurons in the posterior (prrn) and middle (mrrn) rhombencephalic reticular nuclei. The monosynaptic EPSPs were blocked by the glutamate antagonist kynurenic acid and can be considered glutamatergic. The monosynaptic EPSPs were potentiated (up to 12 minutes) following a brief high-frequency stimulation. Stimulation of the ventral thalamus induced rhythmic firing of reticulospinal neurons and elicited rhythmic burst activi...Continue Reading

Citations

Jun 20, 2008·Journal of Neurophysiology·Vatsala Thirumalai, Hollis T Cline
Jan 5, 2011·PLoS Biology·Dominique DerjeanRéjean Dubuc
Feb 3, 1999·Annals of the New York Academy of Sciences·S GrillnerA el Manira
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