Dienogest, a selective progestin, reduces plasma estradiol level through induction of apoptosis of granulosa cells in the ovarian dominant follicle without follicle-stimulating hormone suppression in monkeys

Journal of Endocrinological Investigation
S SasagawaK Mizuguchi

Abstract

Dienogest is a selective progestin that has been shown to arrest ovarian follicular development in women, without affecting gonadotropin secretion. As luteal progesterone or exogeneous progestins are known to suppress ovarian folliculogenesis via the inhibition of gonadotropin secretion, this action of dienogest on ovaries seems to be unique. To examine the underlying mechanism of the antifolliculogenic effect of dienogest, female cynomolgus monkeys were treated with a single oral dose of 0.1 mg/kg dienogest on day 7 of the menstrual cycle. Plasma FSH, estradiol (E2), and progesterone levels were measured up to 15 days after dosing. In an additional experiment, ovaries were excised 24 h after dosing for histological examinations. As a result, plasma E2 level declined within 24 h after dosing, while dienogest did not decreased FSH level prior to E2 decline. After decline of E2 level, the low level of E2 was sustained for more than 11 days. It is considered that a single oral dose of dienogest induced atresia of the dominant follicle. In the histological examination, two out of three animals showed decline in E2 level. The ovarian dominant follicles from these animals showed apoptotic changes in granulosa cells with scattered aro...Continue Reading

References

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Citations

May 2, 2014·Journal of Minimally Invasive Gynecology·Ryoko AsanoHideya Sakakibara
Oct 22, 2013·Medical Molecular Morphology·Japarath PrechapanichOsamu Ishihara
Aug 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Toru YanaseTakumi Kurabayashi
Jul 26, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Toru YanaseTakumi Kurabayashi
Mar 1, 2012·Maturitas·Xiangyan RuanAlfred O Mueck
Oct 21, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·T ShevelevaA Malushko
Dec 17, 2009·Women's Health·Tasuku Harada, Fuminori Taniguchi
Jul 23, 2009·The Journal of Family Planning and Reproductive Health Care·Diana Mansour
Jan 24, 2018·The Journal of Obstetrics and Gynaecology Research·Yasuhiko KamadaHisashi Masuyama
Dec 1, 2010·Hormone Molecular Biology and Clinical Investigation·Alfred O Mueck
Jun 20, 2016·Hormone Molecular Biology and Clinical Investigation·Kah Teik ChewAbdul Ghani Nur Azurah

Related Concepts

STS 557
Estradiol, (16 alpha,17 beta)-Isomer
Follicular Atresia
Follicle Stimulating Hormone
Atretic Follicle
Granulosa Cell
Hormone Antagonists
Macaca fascicularis
Ovarian Cycle
Nandrolone

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