Dienogest in the treatment of endometriosis: systematic review

Archives of Gynecology and Obstetrics
Marina de Paula AndresSergio Podgaec

Abstract

Endometriosis is a prevalent disease that affects 5-15 % of women of reproductive age. The aim of this study is to assess the effect of dienogest in the treatment of endometriosis. The search was applied to electronic databases PubMed, Cochrane, EMBASE and Lilacs until September 2014, in a public tertiary hospital. We performed a systematic literature search of randomized trials comparing dienogest to other medical therapies in the treatment of endometriosis, as well as their references list, using the keywords "dienogest" and "endometriosis" by two independent authors. The data extraction were performed by two authors using predefined data fields. Nine randomized trials were included. Dienogest 2 mg/day was superior to placebo in reducing pelvic pain (27.4 versus 15.1 mm, P < 0.0001), with similar results to buserelin, leuprorelin, leuprolide acetate and triptorelin, in controlling symptoms associated with endometriosis. Dienogest 2 mg/day was effective in reducing endometriotic lesions (11.4 ± 1.71-3.6 ± 0.95, P < 0.001). The extended therapy with dienogest 2 mg/day also showed an improvement in pelvic pain after 24-52 weeks (-22.5 ± 32.1 and -28.4 ± 29.9 mm, respectively) with tolerable side effects. Dienogest should be cons...Continue Reading

References

Jul 28, 2001·The New England Journal of Medicine·D L Olive, E A Pritts
Nov 11, 2005·Human Reproduction Update·Piergiorgio CrosignaniAnthony Luciano
Oct 13, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Günter KöhlerAlfred O Mueck
Dec 23, 2009·The Journal of Obstetrics and Gynaecology Research·Mikio MomoedaYuji Taketani
May 7, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Thomas StrowitzkiChristian Seitz
Sep 14, 2010·Human Reproduction Update·Paolo VercelliniLuigi Fedele
Sep 14, 2010·Revista da Associação Médica Brasileira·Patrick BellelisMaurício Simões Abrão
Oct 12, 2010·Contraception·Regine Sitruk-Ware, Anita Nath
Nov 13, 2010·Human Reproduction·Paolo VercelliniLuigi Fedele
Jun 18, 2011·Archives of Gynecology and Obstetrics·Felice PetragliaThomas Strowitzki
Mar 31, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Thomas StrowitzkiChristian Seitz
Jul 24, 2012·American Journal of Reproductive Immunology : AJRI·Sergio PodgaecMauricio Simoes Abrao
Mar 27, 2013·Human Reproduction·Neil P JohnsonUNKNOWN World Endometriosis Society Montpellier Consortium
Jun 5, 2013·Middle East Fertility Society Journal·Robert N TaylorPaolo Vercellini

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Citations

Oct 30, 2015·Expert Opinion on Pharmacotherapy·Anita L Nelson
Dec 10, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Giovanni GrandiBrett McKinnon
Dec 19, 2015·Fertility and Sterility·Paolo VercelliniEdgardo Somigliana
Jun 5, 2015·Archives of Gynecology and Obstetrics·Juanqing LiJun Lin
Aug 10, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Claudia TostiFelice Petraglia
May 12, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Alexis D GreeneKatherine A Burns
Nov 8, 2016·Fertility and Sterility·Paolo VercelliniSilvano Bosari
Sep 7, 2017·Hormone Molecular Biology and Clinical Investigation·Beng Kwang NgPei Shan Lim
Nov 22, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mohamed MabroukRenato Seracchioli
May 15, 2018·Journal of Sex & Marital Therapy·João Paulo Leonardo-PintoDaniela Angerame Yela
Jul 6, 2018·Expert Opinion on Pharmacotherapy·Simone FerreroFabio Barra
Jul 26, 2018·The Journal of Obstetrics and Gynaecology Research·Taisuke MoriJo Kitawaki
Jun 4, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Silvia VannucciniFelice Petraglia
May 26, 2017·Expert Opinion on Drug Metabolism & Toxicology·Antonio Simone LaganàOnofrio Triolo
Dec 3, 2016·Archives of Gynecology and Obstetrics·Antonio Simone LaganàAndrea Romano
Jun 28, 2018·Drugs·Simone FerreroUmberto Leone Roberti Maggiore
Sep 27, 2018·Case Reports in Obstetrics and Gynecology·Hiroaki TakagiToshiyuki Sasagawa
Mar 9, 2020·Journal of Neuroinflammation·Yajing WeiShuzhong Yao
Dec 26, 2017·Current Obstetrics and Gynecology Reports·Parveen ParasarKathryn L Terry
Oct 5, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Anne OppenheimerArnaud Fauconnier
Dec 20, 2020·Biomedicines·Young Sang KimJae Ho Lee
May 20, 2021·Minerva Obstetrics and Gynecology·Simona MartoneStefano Luisi
Jun 23, 2021·The Journal of Obstetrics and Gynaecology Research·Hiroshi Kobayashi, Shogo Imanaka
Jul 9, 2021·International Journal of Women's Health·Zatul Akmar AhmadMuhammad Iqbal Abdul Hafidz

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