PMID: 15338792Sep 2, 2004Paper

Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects

Respiratory Medicine
J PourazarThomas Sandstrom

Abstract

Epidemiological studies have demonstrated adverse health effects of environmental pollution. Diesel exhaust (DE) is an important contributor to ambient particulate matter pollution. DE exposure has been shown to induce a pronounced inflammatory response in the airways, with an enhanced epithelial expression of IL-8, and Gro-alpha in healthy subjects. The present investigation was aimed to further characterise the epithelial response to DE in vivo, with particular reference to possible TH2 response, in non-atopic healthy subjects. To determine this response, 15 healthy, non-atopic non-smoking subjects with normal lung function were exposed to DE (PM10 300 microg/m3) and filtered air during 1 h on two separate randomised occasions. Bronchoscopy sampling of bronchial mucosal biopsies was performed 6 h after exposure. Immunohistochemical staining were performed using mAb for IL-10, IL-13 and IL-18 expression. DE exposure induced a significant increase in the expression of IL-13 in the bronchial epithelium cells, 2.1 (1.35-4.88) Md (Q1-Q3) vs. air 0.94 (0.53-1.23); P = 0.009. No significant changes were seen in IL-10 and IL-18 expression. This finding suggests an TH2-inflammatory response in the airways of non-atopic healthy individ...Continue Reading

References

Jan 1, 1994·International Archives of Occupational and Environmental Health·B RudellN Stjernberg
Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
Sep 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·K M BrittenW R Roche
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·D Diaz-SanchezA Saxon
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·S VedalJ Blair
Oct 30, 1998·Molecular Medicine Today·P J Barnes, S Lim
Oct 30, 1999·The European Respiratory Journal·L A CameronQ A Hamid
Feb 2, 2000·International Immunology·K TominagaK Nakanishi
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·S S SalviA J Frew
Jul 8, 2000·The European Respiratory Journal·C NordenhällE Adelroth
Aug 8, 2001·The European Respiratory Journal·C NordenhällE Adelroth
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·M YangP S Foster
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R W AtkinsonK Katsouyanni

❮ Previous
Next ❯

Citations

Mar 14, 2014·Environmental Health : a Global Access Science Source·Ala MualaThomas Sandström
Aug 25, 2007·American Journal of Respiratory Cell and Molecular Biology·Sima AllahverdianDelbert R Dorscheid
Jul 31, 2007·Critical Reviews in Toxicology·Maria Luisa Scapellato, Marcello Lotti
Mar 13, 2009·Critical Reviews in Toxicology·Thomas W HesterbergPeter A Valberg
Oct 17, 2015·American Journal of Respiratory and Critical Care Medicine·Jessie Nicodemus-JohnsonCarole Ober
Feb 4, 2016·Seminars in Immunopathology·Armen N AkopianEdward G Brooks
Dec 19, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hiroshi FujishimaHirohisa Saito
Sep 29, 2011·Toxicology and Applied Pharmacology·Ryohei Miyata, Stephan F van Eeden
Mar 20, 2010·The Journal of Allergy and Clinical Immunology·Abdelhabib SemlaliJamila Chakir
Feb 27, 2015·Annals of the New York Academy of Sciences·Frank J Kelly, Julia C Fussell
May 8, 2008·Particle and Fibre Toxicology·Jamshid PourazarThomas Sandström
Jun 5, 2015·Environmental Geochemistry and Health·Frank J Kelly, Julia C Fussell
Jan 2, 2007·Respiratory Medicine·Jenny BossonAnders Blomberg
Sep 30, 2008·Respiratory Medicine·Maria SehlstedtThomas Sandström
Aug 24, 2010·Particle and Fibre Toxicology·Maria SehlstedtAnders Blomberg
Mar 8, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jamshid PourazarThomas Sandström
Apr 21, 2007·American Journal of Respiratory and Critical Care Medicine·Håkan TörnqvistAnders Blomberg
Oct 13, 2017·Environmental and Molecular Mutagenesis·Yufei DaiYuxin Zheng
Jan 12, 2012·Current Opinion in Pulmonary Medicine·Andrew J GhioMichael C Madden
Jul 23, 2020·Small·Mark R Miller, Craig A Poland
Sep 29, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Frank J Kelly, Julia C Fussell
Oct 30, 2015·Particle and Fibre Toxicology·Ala MualaThomas Sandström
Jun 7, 2011·American Journal of Respiratory Cell and Molecular Biology·Tillie-Louise HackettDarryl A Knight
May 19, 2021·Annals of the American Thoracic Society·Matteo BonatoSimonetta Baraldo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.