Diesel exhaust inhalation enhances airway hyperresponsiveness in mice

International Archives of Allergy and Immunology
Y MiyabaraMasaru Sagai

Abstract

Repeated intratracheal instillation of diesel exhaust particles and ovalbumin-induced airway hyperresponsiveness and airway inflammation in mice. However, the effects of daily inhalation of diesel exhaust may differ from the effects of direct instillation. Therefore, mice were exposed to diesel exhaust by inhalation 12 h per day for 3 months. Before the diesel exhaust exposure, ovalbumin was injected intraperitoneally as a sensitization. After 3 weeks of diesel exhaust exposure, these mice were challenged with ovalbumin every 3 week thereafter. Diesel exhaust exposure with antigen challenge induced airway hyperresponsiveness and airway inflammation which was characterized by increased numbers of eosinophils and mast cells in lung tissue. The recruitment of inflammatory cells was accompanied by an increment in goblet cells on bronchial epithelium. Diesel exhaust exposure alone also enhanced airway hyperresponsiveness, but did not induce eosinophilic infiltration and/or an increment in goblet cells. Diesel exhaust inhalation enhanced airway hyperresponsiveness and airway inflammation caused by ovalbumin sensitization in mice.

Citations

Mar 12, 2003·Toxicology and Applied Pharmacology·Takamichi IchinoseTakayuki Shibamoto
May 1, 2001·The Science of the Total Environment·H FujimakiN Ui
Jan 5, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S Parnia, A J Frew
Jan 23, 2004·Biology of Reproduction·Chie FurutaKazuyoshi Taya
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·H FujimakiT Endo
May 2, 2003·American Journal of Respiratory and Critical Care Medicine·Stephanie SénéchalBenoît Wallaert
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Florence Tao, Lester Kobzik
Dec 18, 2013·Particle and Fibre Toxicology·Mark R MillerPatrick W F Hadoke
Dec 7, 2007·Biological & Pharmaceutical Bulletin·Chunmei LiKazuyoshi Taya
Feb 16, 2000·Reviews on Environmental Health·C A Goldsmith, L Kobzik
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S S SalviS Holgate
Jun 21, 2012·Journal of Toxicology and Environmental Health. Part a·Xhevahire HyseniYuh-Chin T Huang
Jul 11, 2006·European Journal of Pharmacology·ChunMei LiKazuyoshi Taya
Jan 30, 2013·The Journal of Toxicological Sciences·Michitaka TanakaKen-ichiro Inoue
Oct 29, 2004·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Shuichi HasegawaShinji Wakamatsu
Jan 5, 2018·Particle and Fibre Toxicology·Sarah Robertson, Mark R Miller
Nov 17, 2009·Journal of Immunotoxicology·Tomoki FukuyamaTadashi Kosaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.