Diet and Contaminants: Driving the Rise to Obesity Epidemics?

Current Medicinal Chemistry
Agostino Di Ciaula, Piero Portincasa

Abstract

The obesity epidemic is spreading worldwide without reversal trend and despite specific policies oriented to dietary habits and lifestyle, which seem to have modest effects. Genetic factors only partly explain the rise, whereas environmental factors seem to play a key role, mainly by gene-environment interactions through epigenetic mechanisms. A number of animal and human studies point to maternal diet, intestinal microbiota and chemicals introduced as contaminants with food, all factors able to increase the risk of obesity. Widely diffused toxics (mainly BPA, phthalates, pesticides) are able to promote obesity in children and adults, mainly by acting on the differentiation pathway linking multipotent stromal stem cell to mature adipocyte, modulating epigenetic factors and influencing a series of mechanisms finally leading to altered dietary habits, increased adipocyte formation and fat storage. Furthermore, the adipose tissue is an important target for several chemicals (mainly POPs) which represent a threat to metabolic health. In conclusion, besides excessive individual energy intake and inadequate lifestyle, other broadly diffused and modifiable factors (mainly ingestion of toxic chemicals with food) seem to have a critical...Continue Reading

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Citations

Sep 1, 2019·Current Pharmaceutical Design·Caroline D VelosoPaulo J Oliveira
Oct 23, 2018·F1000Research·Agostino Di Ciaula, Piero Portincasa
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Feb 6, 2020·World Journal of Pediatrics : WJP·Maria Felicia FaienzaPiero Portincasa
Jun 2, 2020·European Journal of Clinical Investigation·Agostino Di CiaulaUNKNOWN IMC-19 Group

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