Abstract
The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.
References
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Feb 2, 1989·The New England Journal of Medicine·S EndresP C Weber
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·G FernandesR A Good
Feb 1, 1983·Arthritis and Rheumatism·J D PrickettA D Steinberg
Jun 1, 1995·Cellular Immunology·P Yaqoob, P Calder
Oct 1, 1993·Lupus·E Rossi, M Costa
Jan 1, 1993·Annals of Nutrition & Metabolism·J M Black, J E Kinsella
May 1, 1996·The British Journal of Nutrition·B F LinS J Jeng
Apr 1, 1997·Clinical and Experimental Immunology·D A TroyerG Fernandes
Apr 1, 1997·The British Journal of Nutrition·B F LinC C Huang
Jan 1, 1997·Annals of Nutrition & Metabolism·P C Calder
Jun 2, 1998·Lupus·R ReifenY Shoenfeld
Jun 27, 2000·The Journal of Nutrition·B O LimG Fernandes
Citations
May 23, 2012·International Journal of Clinical Practice·G R V Hughes, Y Shoenfeld
Aug 31, 2007·Drugs & Aging·Deana Lazaro
Jul 19, 2011·Autoimmunity Reviews·Chia-Chien Hsieh, Bi-Fong Lin
Mar 13, 2003·Experimental Dermatology·K J McElweeR Hoffmann
Jul 19, 2016·Nutritional Neuroscience·Georges MaaloulyNassim Farès
Feb 14, 2009·Lupus·Y H HongB F Lin
Jan 27, 2019·Experimental and Therapeutic Medicine·Maria-Magdalena ConstantinAnca Raducan
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maximilian ZeydaThomas M Stulnig
Jan 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rafat A SiddiquiWilliam Stillwell
Feb 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaoyang LiuAntonio La Cava
Aug 15, 2020·Frontiers in Immunology·Md Asiful IslamRosline Hassan
Nov 11, 2003·The Journal of Nutrition·Karen J AubornNicholas Chiorazzi
Jun 26, 2021·Scandinavian Journal of Rheumatology·D GorczycaM Szmyrka