PMID: 11315362Apr 24, 2001Paper

Diet and lupus

Lupus
A LeibaY Shoenfeld

Abstract

The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.

References

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Citations

May 23, 2012·International Journal of Clinical Practice·G R V Hughes, Y Shoenfeld
Jul 19, 2011·Autoimmunity Reviews·Chia-Chien Hsieh, Bi-Fong Lin
Jul 19, 2016·Nutritional Neuroscience·Georges MaaloulyNassim Farès
Jan 27, 2019·Experimental and Therapeutic Medicine·Maria-Magdalena ConstantinAnca Raducan
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maximilian ZeydaThomas M Stulnig
Jan 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rafat A SiddiquiWilliam Stillwell
Feb 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaoyang LiuAntonio La Cava
Nov 11, 2003·The Journal of Nutrition·Karen J AubornNicholas Chiorazzi

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.