Diet Composition Affects Liver and Mammary Tissue Transcriptome in Primiparous Holstein Dairy Cows

Animals : an Open Access Journal From MDPI
Shengtao GaoDengpan Bu

Abstract

The objective of the present study was to evaluate the overall adaptations of liver and mammary tissue to a corn stover (CS) compared to a mixed forage (MF) diet in mid-lactation primiparous dairy cows. Twenty-four primiparous lactating Holstein cows were randomly allocated to 2 groups receiving either an alfalfa forage diet (MF, F:C = 60:40) with Chinese wildrye, alfalfa hay and corn silage as forage source or a corn stover forage diet (CS, F:C = 40:60). A subgroup of cows (n = 5/diet) was used for analysis of liver and mammary transcriptome using a 4 × 44K Bovine Agilent microarray chip. The results of functional annotation analysis showed that in liver CS vs. MF inhibited pathways related to lipid metabolism while induced the activity of the potassium channel. In mammary tissue, fatty acid metabolism was activated in CS vs. MF. In conclusion, the analysis of genes affected by CS vs. MF indicated mammary gland responding to lower level of linoleate from the diet (lower in CS vs. MF) by activating the associated biosynthesis metabolic pathway while the liver adaptively activated potassium transport to compensate for a lower K ingestion.

References

Jul 1, 1979·The Journal of Clinical Investigation·S E SteinbergR S Hillman
Mar 1, 1975·Journal of Dairy Science·R A Sibaja, G H Schmidt
Mar 5, 2004·Cellular and Molecular Life Sciences : CMLS·S MandardS Kersten
May 26, 2004·Clinics in Laboratory Medicine·Jennifer P HolstSteven J Soldin
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·R VettorG Federspil
Feb 24, 2006·Nature Reviews. Immunology·Warren StroberTomohiro Watanabe
Mar 16, 2006·Journal of Dairy Science·D E BaumanA L Lock
Feb 17, 2007·Cardiovascular Toxicology·Allan R Brasier
Aug 25, 2007·Pharmacogenomics·Martin LaussChrista Noehammer
Aug 2, 2008·BMC Genomics·Massimo Bionaz, Juan J Loor
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Sep 3, 2010·Annual Review of Physiology·Lin JiaLiqing Yu
Dec 21, 2010·IUBMB Life·Jörg R AschenbachGregory B Penner
Jan 1, 2014·Journal of the Science of Food and Agriculture·Ruiyang ZhangShengyong Mao
Jan 16, 2014·Archives of Animal Nutrition·Rongwei HanJiaqi Wang
Jan 1, 2013·Annual Review of Animal Biosciences·Juan J LoorJames K Drackley
Jan 20, 2015·Journal of Proteome Research·Hui-Zeng SunJian-Xin Liu
May 2, 2017·Canadian Journal of Physiology and Pharmacology·Victoria SidKarmin O
Jun 14, 2017·Journal of Animal Physiology and Animal Nutrition·B WangJ X Liu
May 18, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tomasz BoczekMichael S Kapiloff
Jun 28, 2019·Frontiers in Endocrinology·Meital Charni-NatanVarda Rotter

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Datasets Mentioned

BETA
GSE73980

Methods Mentioned

BETA
biopsies
biopsy
chip
Feature Extraction

Software Mentioned

JMP Genomics
Feature Extraction
ClueGO Database for Annotation , Visualization , and Integrate...
Adobe Illustrator
ClueGO
DAVID
Gene Spring
Dynamic Impact Approach ( DIA )

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