Diet during Pregnancy and Infancy and the Infant Intestinal Microbiome

The Journal of Pediatrics
Jessica H SavageAugusto A Litonjua

Abstract

To determine the association between diet during pregnancy and infancy, including breastfeeding vs formula feeding, solid food introduction, and the infant intestinal microbiome. Infants participating in the Vitamin D Antenatal Asthma Reduction Trial were included in this study (n = 323). Maternal and infant diets were assessed by questionnaire. Infant stool samples were collected at age 3-6 months. Stool sequencing was performed using the Roche 454 platform. Analyses were stratified by race/ethnicity. Breastfeeding, compared with formula feeding, was independently associated with infant intestinal microbial diversity. Breastfeeding also had the most consistent associations with individual taxa that have been previously linked to early-life diet and health outcomes (eg, Bifidobacterium). Maternal diet during pregnancy and solid food introduction were less associated with the infant gut microbiome than breastfeeding status. We found evidence of a possible interaction between breastfeeding and child race/ethnicity on microbial composition. Breastfeeding vs formula feeding is the dietary factor that is most consistently independently associated with the infant intestinal microbiome. The relationship between breastfeeding status an...Continue Reading

Associated Clinical Trials

Citations

Mar 1, 2020·Journal of Neuroscience Research·Hiba Al RubayeNafisa M Jadavji
Sep 25, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Mark A UnderwoodCharles L Bevins
May 30, 2020·Children·Christina L NanceAikaterini Anagnostou
Oct 13, 2020·Frontiers in Pediatrics·Enza D'AuriaCarina Venter
Dec 12, 2020·The Cochrane Database of Systematic Reviews·May Loong TanDavid A Osborn
Jan 21, 2021·Nutrients·Kyoko HasebeMargaret J Morris
Feb 17, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Kiley B Vander WystCorrie M Whisner
Feb 14, 2021·International Journal of Molecular Sciences·Karla Rio-AigeFrancisco José Pérez Cano
Feb 12, 2021·FEMS Microbiology Reviews·Azhar S SindiLisa F Stinson
Apr 9, 2021·Frontiers in Nutrition·Gaëlle BoudrySophie Blat
Apr 10, 2021·Frontiers in Neuroscience·Jessica MaiuoloVincenzo Mollace
Sep 3, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Katariina KoivusaariSuvi M Virtanen
Jul 21, 2021·Annual Review of Nutrition·Saurabh MehtaJulia L Finkelstein

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