Diet for stroke prevention.

Stroke and Vascular Neurology
J David Spence

Abstract

Lifestyle is far more important than most physicians suppose. Dietary changes in China that have resulted from increased prosperity are probably responsible for a marked rise in coronary risk in the past several decades, accelerating in recent years. Intake of meat and eggs has increased, while intake of fruits, vegetables and whole grains has decreased. Between 2003 and 2013, coronary mortality in China increased 213%, while stroke mortality increased by 26.6%. Besides a high content of cholesterol, meat (particularly red meat) contains carnitine, while egg yolks contain phosphatidylcholine. Both are converted by the intestinal microbiome to trimethylamine, in turn oxidised in the liver to trimethylamine n-oxide (TMAO). TMAO causes atherosclerosis in animal models, and in patients referred for coronary angiography high levels after a test dose of two hard-boiled eggs predicted increased cardiovascular risk. The strongest evidence for dietary prevention of stroke and myocardial infarction is with the Mediterranean diet from Crete, a nearly vegetarian diet that is high in beneficial oils, whole grains, fruits, vegetables and legumes. Persons at risk of stroke should avoid egg yolk, limit intake of red meat and consume a diet sim...Continue Reading

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Citations

Nov 15, 2018·Journal of Translational Internal Medicine·J David Spence
Aug 29, 2020·Das Gesundheitswesen·Christoph KowalskiElisabeth Inwald
Apr 25, 2020·International Journal of Environmental Research and Public Health·Federica NistaNatale Musso
Jun 15, 2019·Stroke; a Journal of Cerebral Circulation·Jinhong CaoChuanhua Yu
Nov 15, 2019·Current Treatment Options in Cardiovascular Medicine·Nicholas D OsteraasSarah Song
Aug 23, 2020·Stroke and Vascular Neurology·J David Spence
Mar 7, 2021·Foods·Michihiro Sugano, Ryosuke Matsuoka
May 1, 2021·International Journal of Environmental Research and Public Health·Andrea PiccioniFrancesco Franceschi
Sep 30, 2021·Current Neurology and Neuroscience Reports·Sergio A Ramírez-SalazarJorge G Ortiz García
Nov 25, 2021·Journal of the American Heart Association·Jie XuYongjun Wang

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