PMID: 696822Sep 1, 1978Paper

Diet-induced adipocyte number increase in adult rats: a new model of obesity

The American Journal of Physiology
I M FaustJ Hirsch

Abstract

Adult rats of various strains became obese when they were fed a highly palatable diet for several months. Analysis of their adipose tissue morphology revealed increases in both adipocyte size and number in most depots. Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. Adipocyte number remained at the elevated level achieved during the period of weight gain. Thus, transient dietary obesity in rats results in a persistent obesity of a purely hyperplastic, nonhypertrophic form. Furthermore, the persistence of the cell number increase suggests that it is the result of proliferation or differentiation rather than of only an increase in the lipid content of a pool of very small and normally undetected adipocytes. An analysis of adipose tissue morphology changes during the course of diet-induced weight gain suggests that the achievement of some specific mean adipocyte size triggers the events that culminate in adipocyte number increase. What mechanisms may link adipocyte size to the formation of new adipocytes remains unknown.

References

Jul 22, 1977·Science·I M FaustJ Hirsch
Aug 1, 1976·The American Journal of Physiology·I M FaustJ Hirsch
Oct 1, 1976·The American Journal of Physiology·J G Kral
Jul 1, 1976·Clinics in Endocrinology and Metabolism·J Hirsch, B Batchelor
Jan 1, 1975·Scandinavian Journal of Plastic and Reconstructive Surgery·J G Kral
Dec 1, 1975·The American Journal of Physiology·J W StilesE J Masoro
Nov 1, 1969·The Journal of Clinical Investigation·C H Hollenberg, A Vost
Apr 1, 1973·The Journal of Clinical Investigation·L B SalansR E Weismann
Mar 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·M R GreenwoodJ Hirsch
Sep 1, 1970·The Journal of Nutrition·R SchemmelJ L Gill
May 1, 1971·The Journal of Clinical Investigation·L B SalansE A Sims
Sep 1, 1971·The American Journal of Physiology·M Di Girolamo, S Mendlinger
Sep 1, 1968·The Journal of Clinical Investigation·J L Knittle, J Hirsch
Jun 1, 1962·The Journal of Nutrition·S C PECKHAMH W CARROLL

❮ Previous
Next ❯

Citations

Jun 17, 2020·The Biochemical Journal·Alice E Pollard, David Carling
Jul 2, 2020·Ecology and Evolution·Juliana Castrillon, Susan Bengtson Nash
Nov 24, 2016·American Journal of Physiology. Endocrinology and Metabolism·Yuanyuan WuSusan K Fried
Dec 29, 2017·Global Change Biology·Susan M Bengtson NashDavid McLagan
Mar 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Soo-Min LimYuri Kim
Apr 14, 2019·Nutrients·Paulina PiechowskaSylwia Mildner-Szkudlarz
Jan 16, 2020·Cells·Wonkyoung ChoYoung Mi Park
Aug 26, 2020·International Journal of Molecular Sciences·Noelia Martínez-Sánchez
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston
Aug 2, 2006·Experimental Animals·Koichi NakazatoToshiaki Waga
Nov 28, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mariana SchroederAron Weller
Aug 2, 2018·Frontiers in Physiology·Na Chen, Jiqiu Wang
May 20, 2020·Journal of Developmental Origins of Health and Disease·Diana C Castro-RodríguezElena Zambrano
Oct 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan QinMin Fang
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Prakash Raj PandeyaHyun-Ju Jung
Nov 13, 2020·Archives of Physiology and Biochemistry·Victor Hugo Dantas GuimarãesSérgio Henrique Sousa Santos
May 4, 2016·Journal of Cellular Biochemistry·Ann-Katrin HolikVeronika Somoza
Jul 2, 2019·Marine Environmental Research·Alison DruskatSusan M Bengtson Nash
Jun 30, 1978·Science·I M FaustJ Hirsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.