Diet-induced central obesity and insulin resistance in rabbits

Journal of Animal Physiology and Animal Nutrition
S ZhaoE Liu

Abstract

The present study was designed to examine whether rabbits fed a diet containing high fat and sucrose could develop obesity and insulin resistance (IR), the major pathophysiological features of metabolic syndrome. Male Japanese white rabbits were fed either a normal chow diet (control) or high fat and sucrose diet (HFSD) for 36 weeks. Plasma levels of triglycerides (TG), total cholesterol (TC), glucose and insulin were measured. To evaluate glucose metabolism, we performed an intravenous glucose tolerance test. In addition, we compared adipose tissue accumulation in HFSD-fed rabbits with that in normal rabbits. HFSD constantly and significantly led to an increase in body weight of HFSD-fed rabbits, caused by significantly higher visceral adipose tissue accumulation. Although there were no differences in plasma TG, TC, glucose, insulin levels and blood pressure between the two groups, HFSD-fed rabbits showed impaired glucose clearance associated with higher levels of insulin secretion compared to control rabbits. Our results showed that HFSD induced IR and increased adipose accumulation in rabbits, suggesting that HFSD-fed rabbits may become a model for research on human IR and obesity.

References

Jun 8, 2000·Annals of the New York Academy of Sciences·Y MatsuzawaT Nakamura
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Nov 27, 2002·Circulation·Yoshihisa OkamotoYuji Matsuzawa
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
May 10, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Masashi ShiomiJianglin Fan
Sep 3, 2003·Pharmacology & Therapeutics·Jianglin Fan, Teruo Watanabe
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Junko Hiraoka-YamamotoKatsumi Ikeda
May 11, 2004·Current Diabetes Reports·Mandeep Bajaj, Mary Ann Banerji
Nov 25, 2004·Metabolism: Clinical and Experimental·Enqi LiuJianglin Fan
Dec 18, 2004·Science·Atsunori FukuharaIichiro Shimomura
Jan 22, 2005·Annual Review of Medicine·David E Moller, Keith D Kaufman
Apr 20, 2005·Lancet·Dongfeng GuUNKNOWN InterASIA Collaborative Group
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Jun 7, 2005·Nature Medicine·Gema Medina-Gomez, Antonio Vidal-Puig
Sep 1, 2005·The Journal of Laboratory and Clinical Medicine·Lilach O LermanClaudio Napoli
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Takashi KawaiHitonobu Tomoike
Nov 23, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·James C Russell, Spencer D Proctor

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Citations

Jul 25, 2019·Animals : an Open Access Journal From MDPI·Wilson M LozanoManuel Zarzoso
Jun 10, 2021·Hormone Molecular Biology and Clinical Investigation·Mokrani ZoulikhaSoltani Yacine

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