Abstract
Dietary shifts play an important role in decreased longevity in ruminant livestock. Ruminants evolved as cellulose fermenters adapt to fiber-rich diets. Instead, high-producing ruminants nowadays are commonly fed with grain-based diets to increase intake and productivity. Such diets, however, trade off the health of the animal. One negative aspect of such feeding is related to elevated levels of bacterial endotoxin (lipopolysaccharide, LPS) in the gut lumen and the likelihood of LPS translocation across the gut causing systemic and local (tissue) inflammation with consequences for production and longevity. However, the view for toxicity of gut LPS is oversimplified, overlooking the physicochemistry of LPS and the translocation route that determine the fate and immune reactive activity of LPS within the host. The barrier and defensive mechanisms of rumen morphology and intestinal mucus are understated. LPS cross the epithelial barrier paracellularly through impaired tight-junction and transcellularly through receptor-mediated transcytosis and the lipoprotein pathway transporting lipids. The lipoprotein pathway delivers LPS to the circulation before reaching the liver for detoxification and is believed to be the major natural rou...Continue Reading
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